文献类型：期刊文献

英文题名：Dual regulatory effects of gut microbiota and their metabolites in rheumatoid arthritis: balancing pathogenic and protective mechanisms

作者：Xie, Xingwen[1,2];Chen, Xin[1];Wang, Xuetao[2];Wang, Sunli[2];Qi, Peng[2]

第一作者：Xie, Xingwen

通信作者：Qi, P[1]

机构：[1]Gansu Univ Tradit Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Lanzhou, Peoples R China

第一机构：甘肃中医药大学第二附属医院

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：16

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;Scopus(收录号：2-s2.0-105005028458);WOS:【SCI-EXPANDED(收录号:WOS:001487223600001)】；

基金：The authors acknowledge the use of Biorender to create schematic representations in Figures 1 - 3 .

语种：英文

外文关键词：gut microbiota; intestinal metabolites; gut-joint axis; rheumatoid arthritis; bidirectional regulation

摘要：Rheumatoid arthritis is a chronic autoimmune disorder characterized by destructive, symmetric joint inflammation and synovitis, resulting in substantial disability that profoundly compromises patients' quality of life. Its pathogenesis encompasses complex interactions between genetic and environmental factors. Recent advances in bacterial DNA sequencing technologies have uncovered a significant correlation between the human gut microbiota composition and rheumatoid arthritis progression. Growing clinical and experimental evidence establishes the gut-joint axis as a crucial mediator in rheumatoid arthritis pathogenesis. Comprehensive investigation of gut microbial communities and their metabolites' influence on rheumatoid arthritis mechanisms, coupled with the elucidation of microbiome's bidirectional regulatory effects in disease development, not only deepens our understanding of pathological processes but also establishes a theoretical framework for developing novel diagnostic biomarkers and personalized therapeutic interventions to enhance patient outcomes.