文献类型：期刊文献

英文题名：Immune reprogramming in the bone marrow microenvironment: a new perspective on the bone immune microenvironment of postmenopausal osteoporosis

作者：Li, Dingpeng[1,2];Zheng, Xianli[1,3];Lin, Deming[1];Cheng, Yuan[1];Wang, Zhong[1];Chen, Yangyang[1];Xie, Xingwen[1,3]

第一作者：Li, Dingpeng

通信作者：Xie, XW[1];Xie, XW[2]

机构：[1]Gansu Univ Chinese Med, Lanzhou, Gansu, Peoples R China;[2]Gansu Prov Second Peoples Hosp, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2026

卷号：17

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;Scopus(收录号：2-s2.0-105032515643);WOS:【SCI-EXPANDED(收录号:WOS:001713148100001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. This work was supported by the following: the National Natural Science Foundation of China (General Program) (No. 82374491); National Natural Science Foundation of China (Regional Fund) (Nos. 82160918, 81860864, 82160911); the Central Guidance Local Science and Technology Development Special Project - Innovation Platform for Enhancing the Prevention and Control Capabilities of Multiple Diseases in Gansu Region (YDZX20206200002356); Basic Research Funding from Central Universities (No. 31920210041); Gansu Province Outstanding Talent Program; Gansu Provincial Science and Technology Plan Project (No. 20JR5RA129); Open Project of Gansu Provincial Traditional Chinese Medicine Research Center (No. zyzx-2020-32); Open Project of the Ministry of Education Key Laboratory of Dunhuang Medicine and Translational Research (No. DHYX19-05); Guidance Project of Lanzhou Science and Technology Bureau (2022-ZD-53); Longyuan Young Talent Support Program (Gansu CPC Talent [2022] No. 5); Gansu Provincial Science and Technology Plan Project (No. 25JRRA836); Gansu Major Science and Technology Project (No. 21ZD4FA009); and the Rehabilitation Technology Achievement Research and Translational Application Project of the China Center for Traditional Chinese Medicine Science and Technology Development.

语种：英文

外文关键词：postmenopausal osteoporosis; bone marrow microenvironment; immune reprogramming; bone immunology; inflammatory bone loss; bone immune microenvironment therapy

摘要：Research on postmenopausal osteoporosis (PMOP), a common bone metabolic disease, has traditionally focused on bone loss and imbalance in bone remodeling. However, with the development of bone immunology, the complex interactions between immune cells and bone cells in the bone marrow microenvironment have gradually been revealed, and "immune reprogramming" is considered a key factor driving the persistent bone loss in PMOP. Current evidence indicates that the postmenopausal bone marrow microenvironment undergoes significant structural and functional changes. These changes are characterized by a myeloid bias in hematopoietic stem/progenitor cells, aging of bone marrow mesenchymal stem cells (BMSCs) with a tendency toward differentiation into the adipocyte lineage, an imbalance of key immune cell subpopulations such as M1 and M2 macrophages and Th17 and regulatory T cells (Treg), as well as remodeling of cytokine and chemokine axis networks. Signaling pathways such as RANK/RANKL/OPG, Wnt/beta-catenin, CXCL12-CXCR4, and S1P - along with systemic factors like estrogen deficiency, inflammatory aging, and the gut-bone-immune axis-collectively shape the characteristic bone immune microenvironment of PMOP. Based on this, this article systematically reviews the changes in cell lineage and molecular mechanisms underlying PMOP bone marrow immune reprogramming. It focuses on the key signaling networks in the bone immune microenvironment and their relationship with the mechanisms of existing anti-osteoporosis drugs. Furthermore, it proposes an immunotherapy approach represented by a three-tiered framework: traditional bone-targeted drugs, immune-guided therapy, and comprehensive intervention of the bone marrow microenvironment. Finally, in conjunction with emerging technologies such as multi-omics, single-cell, and spatial omics, this article discusses future directions for constructing a PMOP bone immune map and achieving precise stratification and individualized intervention, aiming to provide a theoretical basis and methodological reference for mechanistic research and bone immune-targeted therapy of PMOP.