文献类型：期刊文献

英文题名：Natural Products: A Promising Therapeutics for Targeting Tumor Angiogenesis

作者：Li, Ruyi[1];Song, Xin[2];Guo, Yanan[3,4];Song, Peng[3,4];Duan, Dongzhu[5,6];Chen, Zhe-Sheng[7]

第一作者：Li, Ruyi

通信作者：Song, P[1];Song, P[2];Duan, DZ[3];Duan, DZ[4];Chen, ZS[5]

机构：[1]Zhengzhou Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Zhengzhou, Peoples R China;[2]Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Res Ctr Tradit Chinese Med Gansu Prov, Lanzhou, Peoples R China;[4]Gansu Univ Chinese Med, Affiliated Hosp, Key Lab Prevent & Treatment Chron Dis Tradit Chin, Lanzhou, Peoples R China;[5]Baoji Univ Arts & Sci, Shaanxi Key Lab Phytochem, Baoji, Peoples R China;[6]Baoji Univ Arts & Sci, Coll Chem & Chem Engn, Baoji, Peoples R China;[7]St Johns Univ, Coll Pharm & Hlth Sci, Queens, NY 11439 USA

第一机构：Zhengzhou Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Zhengzhou, Peoples R China

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Res Ctr Tradit Chinese Med Gansu Prov, Lanzhou, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Key Lab Prevent & Treatment Chron Dis Tradit Chin, Lanzhou, Peoples R China;[3]corresponding author), Baoji Univ Arts & Sci, Shaanxi Key Lab Phytochem, Baoji, Peoples R China;[4]corresponding author), Baoji Univ Arts & Sci, Coll Chem & Chem Engn, Baoji, Peoples R China;[5]corresponding author), St Johns Univ, Coll Pharm & Hlth Sci, Queens, NY 11439 USA.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2021

卷号：11

外文期刊名：FRONTIERS IN ONCOLOGY

收录：;Scopus(收录号：2-s2.0-85118749442);WOS:【SCI-EXPANDED(收录号:WOS:000716482600001)】；

基金：Funding This work was supported by the National Natural Science Foundation of China (81803779); the Gansu Province Science Foundation for Distinguished Young Scholars (20JR10RA348) and the Gansu Province Science Foundation for B Program (1508RJZA018) from Gansu Provincial Sci. & Tech. Department; the Open Project of Research Center of Traditional Chinese Medicine, Gansu Province (zyzx-2020-zx1); the Open Project of Key Laboratory of Prevention and Treatment for Chronic Diseases by TCM in Gansu Province (GSMBKY2015-01); the Gansu Province Health Industry Scientific Research Program Management Project (GWGL2014-53); and the National Natural Science Foundation of Shaanxi Province (2018JQ2051).

语种：英文

外文关键词：tumor angiogenesis; natural products; angiogenic factors; endothelial cell apoptosis; anti-angiogenic mechanism; chemical structures

摘要：Tumor-associated angiogenesis is a key target for anti-cancer therapy. The imbalance between pro-angiogenic and anti-angiogenic signals elicited by tumor cells or tumor microenvironment always results in activating "angiogenic switch". Tumor angiogenesis functions in multi-aspects of tumor biology, including endothelial cell apoptosis, tumor metastasis, and cancer stem cell proliferation. Numerous studies have indicated the important roles of inexpensive and less toxic natural products in targeting tumor angiogenesis-associated cytokines and apoptotic signaling pathways. Our current knowledge of tumor angiogenesis is based mainly on experiments performed on cells and animals, so we summarized the well-established models for angiogenesis both in vitro and in vivo. In this review, we classified and summarized the anti-angiogenic natural agents (Polyphenols, Polysaccharides, Alkaloids, Terpenoids, Saponins) in targeting various tumor types according to their chemical structures at present, and discussed the mechanistic principles of these natural products on regulating angiogenesis-associated cytokines and apoptotic signaling pathways. This review is to help understanding the recent progress of natural product research for drug development on anti-tumor angiogenesis.