文献类型：期刊文献

中文题名：微生态疗法治疗婴幼儿轮状病毒腹泻的疗效及对患儿免疫功能的影响

英文题名：Effect of microecological therapy on rotavirus diarrhea and immunologic function in infants

作者：甄小龙[1];贺沙沙[1];吴丽萍[2]

第一作者：甄小龙

机构：[1]甘肃中医药大学附属医院药学部,甘肃兰州730010;[2]甘肃中医药大学附属医院儿科,甘肃兰州730010

第一机构：甘肃中医药大学第二附属医院

年份：2018

卷号：38

期号：7

起止页码：988

中文期刊名：基础医学与临床

外文期刊名：Basic and Clinical Medicine

收录：CSTPCD;;CSCD:【CSCD_E2017_2018】；

语种：中文

中文关键词：轮状病毒;腹泻;微生态疗法;免疫功能;婴幼儿

外文关键词：rotavirus;diarrhea;microecological therapy;immunologic function;infants

摘要：目的探讨微生态疗法治疗婴幼儿轮状病毒(RV)腹泻的疗效,以及该疗法对患儿免疫功能的影响。方法将150例RV腹泻患儿随机分为对照组和实验组,各75例。对照组给予蒙脱石散治疗,实验组在应用蒙脱石散的同时给予金双歧(双歧杆菌乳杆菌三联活菌片)治疗。观察临床疗效及临床症状,采用胶体金法检测RV抗原,采用流式细胞计量技术和ELISA检测免疫功能。结果实验组总有效率为90.7%,显著高于对照组的74.7%(P<0.05);与对照组比,实验组的止泻时间、退热时间及呕吐症状消失时间均较短(P<0.05);实验组治疗1、2周后的RV病毒抗原转阴率均明显高于对照组(P<0.05);治疗3周后,实验组RV病毒抗原全部转阴,对照组仍有12.0%的阳性率(P<0.05);实验组治疗后的外周血CD3^+、CD4^+和CD4^+/CD8^+比值以及血清免疫球蛋白A(Ig A)、Ig M水平均较治疗前显著升高(P<0.05),并且明显高于对照组(P<0.05);两组治疗期间均未出现不良反应。结论微生态疗法治疗婴幼儿RV腹泻疗效确切,安全性高,并能有效改善患儿的免疫功能。
Objective To investigate the effect of microecological therapy on rotavirus(RV)-induced diarrhea and infants immunologic function in infants.Methods 150 infants with RV diarrhea were randomly divided into the experimental group and the control group.The control group was given the treatment of montmorillonite powder.The experimental group was given live combined bifidobacterium and lactobacillus tablets in addition to montmorillonite powder.The clinical efficacy and the improvement of clinical symptoms were compared between the two groups.RV antigen and immunologic function were detected with colloidal gold method.Immune function was detected by flow cytometry and ELISA.Results The total effective rate of the experimental group was 90.7%,and it was significantly higher than that of the control group which was 74.7%(P<0.05).Compared with the control group,the antidiarrheal time,fever clearance time and disappearance time of vomiting symptoms in the experimental group were shorter(P<0.05).The negative conversion rate of RV virus antigen in the experimental group after 1 and 2 weeks treatment was significantly higher than that in the control group(P<0.05).After 3 weeks treatment,RV virus antigen in the experimental group all turned negative,but the control group still had a positive rate of 12.0%(P<0.05).The peripheral blood CD3+,CD4+and the ratio of CD4+/CD8+in the experimental group after treatment were significantly higher than those before treatment and those in the control group after treatment(P<0.05),the same phenomenon was found in serum immunoglobulin A(IgA)and IgM(P<0.05).No adverse events occurred during the treatment period in the two groups.Conclusions Microecological therapy has an exact curative effect and high safety in the treatment of infantile RV diarrhea,it could effectively improve the immunologic function of the infants.