文献类型：期刊文献

中文题名：头穴透刺对急性脑梗死患者血清超敏C反应蛋白及炎性反应因子水平的影响

英文题名：Effect of Scalp-acupuncture Treatment on Levels of Serum High-sensitivity C-reactive Protein,and Pro-inflammatory Cytokines in Patients with Acute Cerebral Infarction

作者：王金海[1];赵敏[1];鲍英存[1];商俊芳[1];鄢琦[2];张振昶[2];杜小正[3];姜华[1];张武德[1]

第一作者：王金海

机构：[1]兰州大学第二医院中医科,兰州730000;[2]兰州大学第二医院神经内科,兰州730000;[3]甘肃中医学院医学技术学院,兰州730000

第一机构：兰州大学第二医院中医科,兰州730000

年份：2016

卷号：41

期号：1

起止页码：80

中文期刊名：针刺研究

外文期刊名：Acupuncture Research

收录：CSTPCD;;Scopus;北大核心:【北大核心2014】；CSCD:【CSCD2015_2016】；PubMed;

语种：中文

中文关键词：头针;急性脑梗死;超敏C反应蛋白;肿瘤坏死因子-α;白介素-6;白介素-1β

外文关键词：Scalp acupuncture;ACI;hs-CRP;TNF-α;IL-6;IL-1β

摘要：目的:观察头穴透刺对急性脑梗死患者血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF)-α、白介素(IL)-6、IL-1β水平的影响,探讨头针治疗急性脑梗死的机制。方法:将符合纳入标准的61例急性脑梗死患者采用分层区组随机法分为头针组31例,对照组30例。对照组采用常规西医治疗,头针组在对照组治疗的基础上加用头穴透刺,取双侧顶颞前斜线、顶颞后斜线行透穴治疗,每日1次,共7d。于治疗前、第3天、第7天,ELISA法检测血清hs-CRP、TNF-α、IL-6、IL-1β水平;于治疗前、第7天采用脑卒中临床神经功能缺损程度评分量表(NDS)行神经功能缺损评分,评价临床疗效。结果:治疗后两组患者血清hs-CRP、TNF-α、IL-6、IL-1β水平均较治疗前明显降低(P<0.05,P<0.01),且第3天、第7天头针组血清hs-CRP、TNF-α、IL-6、IL-1β水平明显低于对照组(P<0.05,P<0.01)。血清hs-CRP水平与患者NDS评分呈正相关(r=0.497,P<0.01)。试验结束时两组患者NDS评分均明显低于治疗前(P<0.05,P<0.01),且头针组明显低于对照组(P<0.05)。临床有效率分别为头针组96.8%(30/31),对照组86.7%(26/30),头针组优于对照组(P<0.05)。结论:头针可降低急性脑梗死患者血清hs-CRP、TNF-α、IL-6和IL-1β水平,控制脑血管炎性反应。
Objective To observe the influence of scalp acupuncture on levels of high-sensitivity C-reactive protein（hsCRP）,TNF-α,IL-6,and IL-1βlevels in patients with acute cerebral infarction（ACI）,so as to investigate its mechanism underlying improvement of ACI.Methods A total of 61 patients with ACI were randomly allocated to scalp acupuncture group（n=31）and control（medication）group（n=30）.The patients of the control group were routinely treated by administration of Aspirin,Danhong injection,Cytidine Diphosphate for neurotrophy,blood pressure-control and blood-fat lowering medicines,etc.,while those of the scalp acupuncture group were treated by routine treatment with the medicines mentioned above plus daily scalp acupuncture stimulation of bilateral Dingnieqianxiexian[MS 6,penetrative needling from Qianding（GV 21）to Xuanli（GB 6）]and Dingniehouxiexian[MS 7,from Baihui（GV 20）to Qubin（GB 7）].The treatment was conducted once daily for 7days.Serum hsCRP,TNF-α,IL-6,and IL-1βcontents were assayed by using enzyme linked immunosorbnent assay（ELISA）.The therapeutic effects of scalp acupuncture were evaluated by using clinical neurological disfunction scale（NDS,0-45 points for consciousness,gazing,facial palsy,speech,myodynamia,walking-ability）.Results（1）Of the 30 and 31cases in the control and scalp acupuncture groups,5（16.7%）and 8（25.8%）were basically controlled,9（30.0%）and 16（51.6%）experienced remarkable improvement in their symptoms,12（40.0%）and 6（19.4%）were improved,4（13.3%）and 1（3.2%）failed,with the effective rates being 86.7% and 96.8%,respectively.The increased levels of serum hs-CRP,TNF-α,IL-6and IL-1βin ACI patients were reversed on the 3rd and 7th day after scalp acupuncture treatment（P〈0.05,P〈0.01）.（2）A positive correlation existed between the NDS score and the serum levels of hs-CRP（r=0.497,P〈0.01）.（3）NDS scores were obviously decreased in both groups on the 7th day after the treatment compared with their baseline data（P〈0.05,P〈0.01）.Conclusion Scalp acupuncture treatment can improve the ACI patients’ clinical symptoms,probably by reducing ACI induced inflammatory reactions.