文献类型：期刊文献

中文题名：miRNAs介导辐射旁效应研究进展

英文题名：Research progress in miRNAs mediated radiation-induced by stander effect

作者：舒亚妃[1];顾静[1];侯敏[1];舍雅丽[1];刘凯[1];段依璠[1]

第一作者：舒亚妃

机构：[1]甘肃中医药大学,兰州730000

第一机构：甘肃中医药大学

年份：2021

卷号：41

期号：11

起止页码：862

中文期刊名：中华放射医学与防护杂志

外文期刊名：Chinese Journal of Radiological Medicine and Protection

收录：CSTPCD;;Scopus;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：甘肃省自然科学基金(21JR1RA262)。

语种：中文

中文关键词：miRNAs;辐射旁效应;外泌体;

外文关键词：miRNAs;Radiation-induced bystander effect;Exosome

摘要：辐射旁效应是指受辐射的细胞产生信号,并诱导未受辐照的细胞产生反应,即受辐射和未受辐射细胞之间的通讯以及这两种细胞内的信号转导效应。辐射对肿瘤细胞造成杀伤作用的同时,也会产生辐射旁效应给邻近的正常组织带来潜在危险。研究发现,电离辐射可直接改变miRNAs表达,并影响未受辐射的邻近组织中基因的表达,因此,miRNAs可能是受辐射细胞和未受辐射细胞之间信号通路调节的重要物质。本文就miRNAs在辐射旁效应中的作用进行综述。
Radiation-induced bystander effect(RIBE)refers to that irradiated cells release signaling factors and induce responses in nonirradiated cells.In other words,it is the communication between irradiated and nonirradiated cells by intracellular signals.RIBE could influence the efficacy of tumor radiotherapy,but also has potential risk to the normal tissues outside of radiation field.Studies have found that ionizing radiation can induce the alteration of miRNA expression not only in the irradiated cells but also in adjacent nonirradiated tissues,and miRNAs may play an important role in the regulation of signaling pathways between irradiated and nonirradiated bystander cells.This article reviewed the roles of miRNAs in RIBE.