文献类型：期刊文献

英文题名：Amide proton transfer-weighted MRI in predicting pathological types of brain metastases in lung Cancer

作者：Xiang, Xuyang[1];Li, Xiaozhong[2];Lin, Huiting[3];Wang, Xufang[3]

第一作者：Xiang, Xuyang

通信作者：Li, XZ[1]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, 732 Jiayuguan West Rd, Lanzhou 730000, Peoples R China;[2]Med Imaging Ctr, Dept Magnet Resonance Imaging, 732 Jiayuguan West Rd, Lanzhou 730020, Peoples R China;[3]Gansu Univ Chinese Med, Clin Med Coll 1, 732 Jiayuguan West Rd, Lanzhou 730020, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Med Imaging Ctr, Dept Magnet Resonance Imaging, 732 Jiayuguan West Rd, Lanzhou 730020, Peoples R China.

年份：2024

卷号：108

起止页码：59

外文期刊名：MAGNETIC RESONANCE IMAGING

收录：;Scopus(收录号：2-s2.0-85184594492);WOS:【SCI-EXPANDED(收录号:WOS:001182219500001)】；

语种：英文

外文关键词：Amide proton transfer; Brain metastases; Lung cancer; Magnetic resonance imaging

摘要：Most brain metastases originate from lung cancer. The majority of cases of lung cancer can be categorized into squamous carcinoma and adenocarcinoma,necessitating distinct clinical treatments and yielding diverse prognoses.Therefore,accurate preoperative evaluation of pathological types through imaging techniques is essential. The objective of this study is to assess the capability of amide proton transfer-weighted(APTw) MRI in predicting the pathological types of brain metastases in lung cancer.Additionally,it seeks to evaluate whether APTw MRI can provide additional value to diffusion-weighted imaging(DWI) at MRIIn this study,a total of 32 participants(mean age,60 +/- 9 years;14 men) underwent evaluation,comprising 9 with squamous carcinoma and 23 with adenocarcinoma.Interestingly,adenocarcinoma demonstrated elevated APTw values(2.70 +/- 0.81% vs 1.82 +/- 0.47%;P = 0.001) and a higher apparent diffusion coefficient(ADC) value(1.00 +/- 0.40 x 10(-3) mm(2)/s vs 0.77 +/- 0.13 x 10(-3) mm(2)/s;P<0.05) in comparison to squamous carcinoma. The area under the receiver operating characteristic curve(AUC) of APTw and ADC in distinguishing between squamous carcinoma and adenocarcinoma were found to be 0.84 and 0.63,respectively.Moreover,the combined area under the receiver operating characteristic curve of the two techniques is 0.84. Amide proton transfer-weighted has the potential to predict the pathological types of brain metastases in lung cancer.