文献类型：期刊文献

英文题名：Research progress of targeted therapy regulating Th17/Treg balance in bone immune diseases

作者：Wang, Xiaxia[1];Sun, Bai[1];Wang, Yujie[1];Gao, Peng[2];Song, Jiayi[2];Chang, Weirong[2];Xiao, Zhipan[1];Xi, Yongbin[3];Li, Zhonghong[4];An, Fangyu[5];Yan, Chunlu[1]

第一作者：王学香;王小霞

通信作者：Yan, CL[1];An, FY[2]

机构：[1]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Sch Basic Med, Lanzhou, Gansu, Peoples R China;[3]No 2 Peoples Hosp Lanzhou, Orthopaed Dept, Lanzhou, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Pathol Res Ctr, Lanzhou, Gansu, Peoples R China;[5]Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：15

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;Scopus(收录号：2-s2.0-85184690272);WOS:【SCI-EXPANDED(收录号:WOS:001159597300001)】；

基金：We would like to thank Editage (www.editage.cn) for English language editing.

语种：英文

外文关键词：rheumatoid arthritis; postmenopausal osteoporosis; targeted therapy; Th17/Treg equilibrium; bone immunity

摘要：Rheumatoid arthritis (RA) and postmenopausal osteoporosis (PMOP) are common bone-immune diseases. The imbalance between helper (Th17) and regulatory T cells (Tregs) produced during differentiation of CD4+ T cells plays a key regulatory role in bone remodelling disorders in RA and PMOP. However, the specific regulatory mechanism of this imbalance in bone remodelling in RA and PMOP has not been clarified. Identifying the regulatory mechanism underlying the Th17/Treg imbalance in RA and PMOP during bone remodelling represents a key factor in the research and development of new drugs for bone immune diseases. In this review, the potential roles of Th17, Treg, and Th17/Treg imbalance in regulating bone remodelling in RA and PMOP have been summarised, and the potential mechanisms by which probiotics, traditional Chinese medicine compounds, and monomers maintain bone remodelling by regulating the Th17/Treg balance are expounded. The maintenance of Th17/Treg balance could be considered as an therapeutic alternative for the treatment of RA and PMOP. This study also summarizes the advantages and disadvantages of conventional treatments and the quality of life and rehabilitation of patients with RA and PMOP. The findings presented her will provide a better understanding of the close relationship between bone immunity and bone remodelling in chronic bone diseases and new ideas for future research, prevention, and treatment of bone immune diseases.