文献类型：期刊文献

中文题名：肥胖和中心性肥胖对高血压的交互作用分析

英文题名：Interaction between obesity/central obesity and hypertension

作者：王亮亮[1];黄瑜[1];郭伟[1];魏兴民[1];范宁[1];赵贵雪[1];颉亚辉[1];马东京[1];王云超[1];王新华[1];吴建军[1]

第一作者：王亮亮

机构：[1]甘肃中医药大学公共卫生学院,甘肃兰州730000

第一机构：甘肃中医药大学公共卫生学院

年份：2022

卷号：34

期号：2

起止页码：129

中文期刊名：预防医学

外文期刊名：CHINA PREVENTIVE MEDICINE JOURNAL

收录：CSTPCD

基金：甘肃省卫健委卫生健康管理项目(31340301);甘肃省重大疾病分子医学与中医药防治研究重点实验室新型冠状病毒防治研究专项(FZYX20-13);甘肃省高等学校产业支撑计划项目(2020C-36)。

语种：中文

中文关键词：高血压;肥胖;中心性肥胖;交互作用

外文关键词：hypertension;obesity;central obesity;interaction

摘要：目的分析肥胖和中心性肥胖对高血压患病影响的交互作用,为制定高血压防控措施提供依据。方法于2018年9—12月,采用多阶段随机抽样方法抽取甘肃省白银市白银区35~75岁居民进行问卷调查和体格检查;采用logistic回归模型分析肥胖与中心性肥胖对高血压影响的交互作用,采用ANDERSSON等编制的Excel表计算交互作用指数(SI)、相对超额危险度比(RERI)和归因比(AP)等交互作用指标。结果发放调查问卷6246份,回收有效问卷6169份,回收有效率为98.77%。调查男性3038人,占49.25%;女性3131人,占50.75%。年龄为(52.05±8.78)岁。检出肥胖832例,占13.49%;中心性肥胖2278例,占36.93%。高血压粗患病率为35.89%,标化患病率为33.05%。多因素logistic回归分析结果显示,肥胖(OR=2.020,95%CI:1.705~2.393)和中心性肥胖(OR=1.622,95%CI:1.433~1.836)与高血压患病均有统计学关联;肥胖和中心性肥胖对高血压患病的影响不存在相乘交互作用(OR=1.011,95%CI:0.655~1.560),也不存在相加交互作用(SI=1.405,95%CI:0.815~2.424;RERI=0.658,95%CI:-0.298~1.614;AP=0.201,95%CI:-0.075~0.476)。结论肥胖和中心性肥胖增加高血压患病风险,但未发现两者存在交互作用。
Objective To examine the effects of obesity and central obesity on hypertension,so as to provide insights in?to the prevention and control measures of hypertension.Methods From September to December 2018,residents at ages of 35 to 75 years were sampled using the multi-stage random sampling method in Baiyin District,Baiyin City,Gansu Province,and subjected to questionnaire surveys and physical examinations.The interaction between obesity/central obesi?ty and hypertension was evaluated using logistic regression analysis.The synergy index(SI),relative excess risk due to interaction(RERI)and attributable proportion due to interaction(AP)were calculated using Excel compiled by Anders?son et al.Results A total of 6246 questionnaires were allocated and 6169 valid questionnaires were recovered,with an effective recovery rate of 98.77%.The respondents included 3038 men(49.25%)and 3131 women(50.75%),with a mean age of(52.05±8.78)years.There were 832 respondents with obesity(13.49%)and 2278 with central obesity(36.93%).The crude and standardized prevalence rates of hypertension were 35.89%and 33.05%,respectively.Multivariable logistic regression analysis showed that obesity(OR=2.020,95%CI:1.705-2.393)and central obesity(OR=1.622,95%CI:1.433-1.836)were statistically associated with hypertension.There was no multiplicative interaction between obesity or central obesity and hypertension(OR=1.011,95%CI:0.655-1.560),and no additive interaction was detected between obesity or central obesityand hypertension(SI=1.405,95%CI:0.815-2.424;RERI=0.658,95%CI:-0.298 to 1.614;AP=0.201,95%CI:-0.075 to 0.476).Conclusions Obesity and central obesity increase the risk of hypertension;however,no interaction is detected between obesity or central obesity and hypertension.