文献类型：期刊文献

中文题名：线粒体自噬在糖尿病视网膜病变中的作用机制及中医药干预研究进展

英文题名：Research progress on the mechanism of mitophagy in diabetic retinopathy and the intervention of traditional Chinese medicine

作者：高英[1];罗向霞[2];张花治[1];任钰妍[1];胡亦明[1];代明丽[1]

第一作者：高英

机构：[1]甘肃中医药大学,甘肃省兰州市730000;[2]甘肃中医药大学第一附属医院,甘肃省兰州市730000

第一机构：甘肃中医药大学

年份：2026

卷号：46

期号：6

起止页码：492

中文期刊名：眼科新进展

外文期刊名：Recent Advances in Ophthalmology

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金资助项目(编号:82360955);甘肃省自然科学基金项目(编号:24JRRA566)。

语种：中文

中文关键词：糖尿病视网膜病变;线粒体自噬;作用机制;中医药治疗;研究进展

外文关键词：diabetic retinopathy;mitophagy;mechanism;traditional Chinese medicine therapy;research progress

摘要：糖尿病视网膜病变(DR)是糖尿病患者常见且严重的微血管并发症,是导致患者视力丧失的主要致盲性眼病,其病理机制涉及由高糖环境引起的代谢紊乱、氧化应激、炎症反应及线粒体功能障碍等方面。线粒体功能障碍是导致DR细胞损伤的核心病理基础。线粒体自噬作为线粒体质量控制的关键机制,通过选择性地清除受损或功能失常的线粒体,在维护视网膜神经细胞稳态方面扮演着至关重要的角色。中医药因其多成分、多靶点、多途径等特性,对靶向调控线粒体自噬有显著优势。本综述聚焦线粒体自噬在DR进展中的作用机制及其与部分中医药有效成分的关联,探讨中医药调控线粒体自噬在防治DR细胞损伤方面的优势及作用,为DR的机制研究及新药开发提供新的理论基础和临床应用前景。
Diabetic retinopathy(DR)is a common and severe microvascular complication in diabetic patients,serving as the primary blinding ocular disease leading to vision loss.Its pathological mechanisms involve metabolic disorders,oxidative stress,inflammatory responses,and mitochondrial dysfunction caused by hyperglycemic environments.Mitochondrial dysfunction represents the core pathological basis for DR cell damage.Mitophagy,as a key mechanism of mitochondrial quality control,plays a crucial role in maintaining retinal neuronal homeostasis by selectively eliminating damaged or dysfunctional mitochondria.Traditional Chinese medicine(TCM)has significant advantages in targeted regulation of mitophagy due to its characteristics of multi-components,multi-targets,and multi-pathways.This review focuses on the mechanisms of mitophagy in DR progression and its association with certain effective components of TCM,explores the advantages and effects of TCM in regulating mitophagy for preventing and treating DR-induced cellular damage,and provides new theoretical foundations and clinical application prospects for DR mechanism research and drug development.