文献类型：期刊文献

英文题名：Acute myocardial infarction and transient elevated anticardiolipin antibody in a young adult with possible familial hypercholesterolemia: a case report: Anticardiolipin antibody and myocardial infarction

作者：Su, Xin[1,2];Wang, Aqian[1,2];Zhu, Hai[1];Su, Hongling[1];Duan, Yichao[1,3];Wu, Shanlian[2];Zhang, Min[4];Huang, Yan[1];Zhou, Xing[5];Cao, Yunshan[1]

第一作者：Su, Xin;苏祥

通信作者：Cao, YS[1];Zhou, X[2]

机构：[1]Lanzhou Univ, Gansu Prov Hosp, Dept Cardiol, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Sch Clin Med, Lanzhou 730000, Gansu, Peoples R China;[3]Ningxia Med Univ, Sch Clin Med, Lanzhou 730000, Gansu, Peoples R China;[4]Lanzhou Univ, Gansu Prov Hosp, Dept Pathol, Lanzhou 730000, Gansu, Peoples R China;[5]Lanzhou Univ, Gansu Prov Hosp, Dept Radiol, Lanzhou 730000, Gansu, Peoples R China

第一机构：Lanzhou Univ, Gansu Prov Hosp, Dept Cardiol, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Gansu Prov Hosp, Dept Cardiol, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Lanzhou Univ, Gansu Prov Hosp, Dept Radiol, Lanzhou 730000, Gansu, Peoples R China.

年份：2019

卷号：19

外文期刊名：BMC CARDIOVASCULAR DISORDERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000473135100001)】；

基金：This work was supported by the National Natural Science Foundation of China (81460072) and CAS "Light of West China" Program where the publication fees are from.

语种：英文

外文关键词：Familial hypercholesterolemia; Thrombosis; Myocardial infarction; Anticardiolipin antibody

摘要：BackgroundFamilial hypercholesterolemia (FH) can lead to premature coronary heart disease. Anticardiolipin antibody may be a contributor for thrombosis. Here, we report an adult with possible FH suffered from premature myocardial infarction that may be triggered by transient increased anticardiolipin antibody.Case presentationA 29-year-old male had presented with a history of 2-h chest pain and numbness of left upper arm before 5days. The electrocardiogram (ECG) had demonstrated inferior wall myocardial infarction (MI). Five days later he was admitted to our hospital and diagnosed as acute MI and possible FH (premature coronary heart disease, low density lipoprotein cholesterol of 5.90mmol/L) with increased anticardiolipin antibody (up to 120 RU/ml). Other auto-antibodies including 2-glicoprotein antibodies IgM, IgA, IgG, lupus anticoagulant (LA), antinuclear antibodies, anti-myocardial antibody were normal. Coronary artery angiography (CAG) showed right coronary artery was total occlusion from the middle segment. Then he underwent percutaneous coronary intervention with a stent. Four days later, he was discharged with complete recovery. CAG showed intra-stent restenosis and anticardiolipin antibody level was normal and the patient had no any symptoms at 6-month follow-up.ConclusionsTransient elevated anticardiolipin antibody may be a trigger or biomarker of cardiac thrombotic events in younger atherosclerotic patients.