文献类型：期刊文献

中文题名：基于藏医古籍文献的失眠症藏药方剂配伍规律及药性特征研究

英文题名：Research on the compatibility rules and medicinal properties of Tibetan prescriptions for insomnia based on ancient Tibetan medical literature

作者：英木草[1];公保甲[2];普华加[1];贡保东知[2]

第一作者：英木草

机构：[1]碌曲县玛艾镇社区卫生服务中心中藏医科,甘肃甘南747200;[2]甘肃中医药大学藏医学院,甘肃甘南747000

第一机构：碌曲县玛艾镇社区卫生服务中心中藏医科,甘肃甘南747200

年份：2025

卷号：42

期号：6

起止页码：62

中文期刊名：甘肃中医药大学学报

外文期刊名：Journal of Gansu University of Chinese Medicine

基金：甘肃中医药大学2024年教学研究与改革项目(YBXM-2024-35);甘肃省教育厅科技创新项目(2025QB-071);甘肃(甘南)藏医药“医-药-护”研究与转化协同创新中心阶段性成果。

语种：中文

中文关键词：失眠症;藏药;方剂配伍;药性;用药规律

外文关键词：insomnia;Tibetan medicine;formulation compatibility;medicinal properties;medication patterns

摘要：目的探讨藏医古籍文献中治疗失眠症的藏药方剂配伍规律及药性特点。方法收集藏医古籍中主治失眠症的方剂,采用Microsoft Excel 2019软件进行频数统计,采用SPSS 25.0软件进行描述性统计、因子分析及聚类分析,利用Gephi 0.9.2绘制药物关联聚类网络图,采用IBM SPSS Modeler 18.0进行药物关联规则分析。结果共筛选出治疗失眠症的藏药方剂81首,涉及药物86味。其中高频药物包括肉豆蔻、孜然芹、牛奶、丁香、白豆蔻等;复杂网络分析显示,肉豆蔻、诃子、江孜乌头、川木香、沉香、丁香为核心用药;聚类分析将药物聚为5类,C1类以温胃健脾、消食宁心类药物为主,具有治疗隆病及心脏病的作用;C2类为消食散寒类药物,主要针对隆病、培根病;C3类以清热祛寒、止痛类药物为主;C4类以醒脑安神类药物为主;C5类以温胃散寒、助消化类药物为主。因子分析提取出6个公因子,反映藏医治疗失眠症时多采用辨证配伍,以消隆、温胃、散寒、健脾、止痛及治疗心脏与命脉病类药物为主;药性特征方面,相关药物的主要药味为辛、甘,三化味以温性为主,药性多属热、润,药效则以润、重、锐为主。结论藏医治疗失眠症的核心机制在于通过调和隆与赤巴的紊乱,实现宁心安神、镇静止痛、抗抑郁及抗焦虑功效;同时重视运用胃肠道调节药物改善消化功能及胃火状态,以促进食物精华吸收与秽物排泄,通过调和三因、抑制疼痛,最终有效改善失眠症状。
Objective To explore the compatibility patterns and medicinal properties of Tibetan medicinal formulations for treating insomnia as recorded in ancient Tibetan medical texts.Methods Formulations primarily indicated for insomnia in ancient Tibetan medical literature were collected.Frequency statistics were performed using Microsoft Excel 2019,while descriptive statistics,factor analysis,and cluster analysis were conducted with SPSS 25.0.A drug association clustering network diagram was generated using Gephi 0.9.2,and association rule analysis of drugs was carried out with IBM SPSS Modeler 18.0.Results A total of 81 Tibetan medicinal formulations for treating insomnia were screened,involving 86 medicinal ingredients.High-frequency drugs included Myristica fragrans,Cuminum cyminum,milk,Syzygium aromaticum,and Elettaria cardamomum.Complex network analysis identified Myristica fragrans,Terminalia chebula,Aconitum ludlowii,Dolomiaea souliei,Aquilaria agallocha,and Syzy-gium aromaticum as core medications.Cluster analysis categorized the drugs into five groups:C1 primarily consisted of drugs for warming the stomach,strengthening the spleen,promoting digestion,and calming the heart,with effects on treating rLung disorders and heart diseases;C2 included drugs for promoting digestion and dispelling cold,mainly targeting rLung and Badkan disorders;C3 comprised drugs for clearing heat,dispelling cold,and relieving pain;C4 mainly consisted of mind-refreshing and tranquilizing drugs;C5 mainly consisted of stomach-warming,cold-dispelling,and digestion-promoting drugs.Factor analysis extracted six common factors,reflecting the common use of syndrome differentiation and compatibility in Tibetan medicine for insomnia,focusing on eliminating rLung,warming the stomach,dispelling cold,strengthening the spleen,relieving pain,and treating heart and life channel diseases.In terms of medicinal properties,the primary tastes of the relevant drugs were pungent and sweet,with the post-digestive taste predominantly warm.The medicinal properties are predominantly hot and moist;the therapeutic effects are mainly characterized by moistening,heaviness,and sharpness.Conclusion The core mechanism of Tibetan medicine in treating insomnia lies in harmonizing the disorders of rLung and mKhris-pa to achieve heart-calming,mind-tranquilizing,sedative,analgesic,antidepressant,and anti-anxiety effects.Simultaneously,emphasis is placed on using gastrointestinal-regulating drugs to improve digestive function and stomach heat,thereby promoting the absorption of food essence and the excretion of waste.By harmonizing the three humors and suppressing pain,insomnia symptoms are effectively alleviated.