文献类型：期刊文献

中文题名：PI3K-AKT信号通路调控慢阻肺气道重塑及中药干预作用研究新进展

英文题名：Traditional Chinese Medicine Regulates Airway Remodeling of Chronic Obstructive Pulmonary Disease via PI3K-AKT Signaling Pathway:a Review

作者：梁可克[1];王志旺[1,2];黄柯婷[1];赵跃[1];李济阳[1];杜玥[1];席建宏[1]

第一作者：梁可克

机构：[1]甘肃中医药大学药学院,兰州730000;[2]陇药产业创新研究院,兰州730000

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2024

卷号：40

期号：5

起止页码：103

中文期刊名：中药药理与临床

外文期刊名：Pharmacology and Clinics of Chinese Materia Medica

收录：;北大核心:【北大核心2023】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金(编号:82260852、81460668);甘肃省自然科学基金(编号:20JR5RA183、1606RJZA011、1310RJZA086)。

语种：中文

中文关键词：慢阻肺;气道重塑;磷酯酰肌醇3激酶/蛋白激酶B;信号通路;调控机制;中药

外文关键词：Chronic obstructive pulmonary disease;Airway remodeling;PI3K-AKT signaling pathway;Regulatory mechanism;Traditional Chinese medicine

摘要：慢性阻塞性肺疾病(COPD)简称慢阻肺,是一种以渐进性且不完全可逆的肺气流阻塞为特征的慢性气道炎症性疾病,炎症引起的以组织增生为主的气道重塑是慢阻肺疾病过程中的肺组织病理学基础,也是引起慢阻肺气流受限的关键因素。近年来,大量研究证实磷酯酰肌醇3激酶(PI3K)/蛋白激酶B(AKT)信号通路可通过调控上皮间充质转化(EMT)、基质金属蛋白酶(MMPs)、哺乳动物雷帕霉素靶蛋白(mTOR)、表皮生长因子受体(EGFR)以及核因子-κB(NF-κB)等而参与慢阻肺气道重塑。中医药在治疗慢阻肺等慢性复杂性疾病过程中有明显的优势,而调节PI3K/AKT信号通路是其防治慢阻肺的作用机制之一,但目前国内外对该领域系统性回顾及总结较少。基于此,本文就近年来PI3K/AKT信号通路参与慢阻肺气道重塑的调控机制及中药干预作用进行综述,以期为慢阻肺的基础研究与新药研发提供理论依据。
Chronic obstructive pulmonary disease(COPD)is a chronic airway inflammatory disease characterized by progressive and incompletely reversible pulmonary airflow obstruction.Airway remodeling induced by chronic inflammation,which is mainly caused by tissue proliferation,is the histopathological basis and a key factor causing airflow limitation in COPD.Phosphoinositol-3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is involved in airway remodeling in COPD by regulating epithelial-mesenchymal transition(EMT),epidermal growth factor receptor(EGFR),nuclear factor-κB(NF-κB),mammalian target of rapamycin(mTOR),and matrix metalloproteinases(MMPs).Traditional Chinese medicine has obvious advantages in the treatment of chronic and complex diseases such as COPD,and the regulation of PI3K/AKT signaling pathway is one of the mechanisms of the prevention and treatment of COPD.However,there are few systematic reviews and conclusions in this field at home and abroad.This article reviews the research progress in the regulatory mechanism of PI3K/AKT signaling pathway involved in airway remodeling in COPD and the intervention effect of traditional Chinese medicine,aiming to provide a theoretical basis for the fundamental research and drug development for COPD.