文献类型：期刊文献

英文题名：Hyperhomocysteinemia-Driven Ischemic Stroke: Unraveling Molecular Mechanisms and Therapeutic Horizons

作者：Li, Bin[1];Kou, Yushun[1];Zhang, Lingna[1];Yi, Lin[1]

第一作者：Li, Bin

通信作者：Yi, L[1]

机构：[1]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：13

期号：7

外文期刊名：FOOD SCIENCE & NUTRITION

收录：;Scopus(收录号：2-s2.0-105009630158);WOS:【SCI-EXPANDED(收录号:WOS:001537430700044)】；

基金：The authors have nothing to report.

语种：英文

外文关键词：folate; homocysteine; hyperhomocysteinemia; ischemic stroke; vitamin

摘要：Homocysteine is a toxic intermediate in the metabolism of methionine, and impaired homocysteine metabolism can lead to hyperhomocysteinemia, whose clinical relevance to ischemic stroke has been confirmed by many studies and is considered an independent risk factor for ischemic stroke. This article reviews and analyzes studies related to ischemic stroke due to hyperhomocysteinemia. Firstly, the mechanism of hyperhomocysteinemia was examined, and it was clarified that hyperhomocysteinemia is the result of mutations in the genes of key enzymes involved in homocysteine metabolism or nutritional disorders of cofactors involved in homocysteine metabolism. Secondly, we reviewed that hyperhomocysteinemia may lead to a series of pathological processes such as vascular injury, thrombosis, and vasoconstriction through the mechanisms of inflammation and oxidative stress, neurotoxicity, and epigenetic dysregulation, which ultimately lead to the development of ischemic stroke. The article also provides a review of research on the prevention and treatment of ischemic stroke associated with hyperhomocysteinemia, specifically describing three large clinical vitamin supplementation trials, which, despite the heterogeneity of findings, provide partial evidence for prevention. This review will provide some insights and thoughts for studying the biological mechanisms of hyperhomocysteinemia-associated ischemic stroke and exploring novel therapies for its prevention and treatment.