文献类型：期刊文献

英文题名：Astragalus polysaccharide inhibits radiation-induced bystander effects by regulating apoptosis in Bone Mesenchymal Stem Cells (BMSCs)

作者：Zhang, Yi-Ming[1];Zhang, Li-Ying[1];Zhou, Heng[2,3];Li, Yang-Yang[1];Wei, Kong-Xi[1];Li, Cheng-Hao[1];Zhou, Ting[1];Wang, Ju-Fang[2,3];Wei, Wen-Jun[2,3];Hua, Jun-Rui[2,3];He, Yun[1];Hong, Tao[1];Liu, Yong-Qi[1]

第一作者：张艺梦

通信作者：Liu, YQ[1]

机构：[1]Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou, Peoples R China;[2]Chinese Acad Sci, Inst Modern Phys, Key Lab Space Radiobiol Gansu Prov, Lanzhou, Peoples R China;[3]Chinese Acad Sci, Inst Modern Phys, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2020

卷号：19

期号：22

起止页码：3195

外文期刊名：CELL CYCLE

收录：;Scopus(收录号：2-s2.0-85094861566);WOS:【SCI-EXPANDED(收录号:WOS:000582898300001)】；

基金：This study was supported by the National Natural Science Foundation of China [Nos. 81973595 and 82004094]; Collaborative Innovation Project of Chinese and Tibetan Medicine [No. XBXT2015-1], Project of Gansu Provincial Education Department [No. 2015A-095] and Project of Lanzhou Municipal Science and Technology Bureau[No. 2015-2-48].

语种：英文

外文关键词：APS; RIBE; BMSCs; Astragalus Polysaccharide; Bystander Effect; Apoptosis

摘要：The purpose of this study was to investigate the effects of astragalus polysaccharides (APS) on the proliferation and apoptosis of bone marrow mesenchymal stem cells (BMSCs) induced by X-ray radiation-induced A549 cells bystander effect (RIBE), and to explore their mechanisms. In this study, APS increased the reduced cell proliferation rate induced by RIBE and inhibiting the apoptosis of bystander cells. In terms of mechanism, APS up-regulates the proteins Bcl-2, Bcl-xl, and down-regulates the proteins Bax and Bak, which induces a decrease in mitochondrial membrane potential, which induces the release of Cyt-c and AIF, which leads to caspase-dependent and caspase-independent pathway to cause apoptosis. In addition, we believe that ROS may be the main cause of these protein changes. APS can inhibit the generation of ROS in bystander cells and thus inhibit the activation of the mitochondrial pathway, further preventing cellular damage caused by RIBE.