文献类型：期刊文献

英文题名：Reprogramming of glucose metabolism: Metabolic alterations in the progression of osteosarcoma

作者：An, Fangyu[1];Chang, Weirong[2];Zhang, Jie[2];Li, Zhonghong[1];Gao, Peng[2];Wang, Yujie[3];Xiao, Zhipan[3];Yan, Chunlu[3]

第一作者：安方玉

通信作者：Yan, CL[1]

机构：[1]Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Sch Basic Med, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：44

外文期刊名：JOURNAL OF BONE ONCOLOGY

收录：;Scopus(收录号：2-s2.0-85182571906);WOS:【SCI-EXPANDED(收录号:WOS:001161320100001)】；

基金：This study was supported by the Gansu Province Higher Education Innovation Fund Project (2022A-072); the Young Doctor Fund Program of Colleges and Universities, Gansu Province (2022QB-091) and the Key Scientific Research Program of "Double first-class", Gansu Province (GSSYLXM-05).

语种：英文

外文关键词：Osteosarcoma; Glucose metabolism; Key enzymes; Signaling pathways; Targeted therapy

摘要：Metabolic reprogramming is an adaptive response of tumour cells under hypoxia and low nutrition conditions. There is increasing evidence that glucose metabolism reprogramming can regulate the growth and metastasis of osteosarcoma (OS). Reprogramming in the progress of OS can bring opportunities for early diagnosis and treatment of OS. Previous research mainly focused on the glycolytic pathway of glucose metabolism, often neglecting the tricarboxylic acid cycle and pentose phosphate pathway. However, the tricarboxylic acid cycle and pentose phosphate pathway of glucose metabolism are also involved in the progression of OS and are closely related to this disease. The research on glucose metabolism in OS has not yet been summarized. In this review, we discuss the abnormal expression of key molecules related to glucose metabolism in OS and summarize the glucose metabolism related signaling pathways involved in the occurrence and development of OS. In addition, we discuss some of the targeted drugs that regulate glucose metabolism pathways, which can lead to effective strategies for targeted treatment of OS.