文献类型：期刊文献

英文题名：The impact of histone lactylation on the tumor microenvironment and metabolic pathways and its potential in cancer therapy

作者：Zhou, Juanhong[1];Ma, Xinyun[1];Liu, Xiaofeng[1];Liu, Yang[1];Fu, Jiaojiao[1];Qi, Yaling[1];Liu, Huiling[2]

第一作者：Zhou, Juanhong

通信作者：Liu, HL[1]

机构：[1]Gansu Univ Chinese Med, Gansu Prov Hosp, Clin Med Coll 1, Lanzhou, Peoples R China;[2]Gansu Prov Hosp, Dept Obstet & Gynecol, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Obstet & Gynecol, Lanzhou, Gansu, Peoples R China.

年份：2024

外文期刊名：GENES & GENOMICS

收录：;Scopus(收录号：2-s2.0-85200952609);WOS:【SCI-EXPANDED(收录号:WOS:001288497200002)】；

基金：The authors would like to express our heartfelt gratitude to all the authors for their significant contributions to this study. Additionally, we extend our profound appreciation to Dr. Peng Xia from the School of Basic Medical Sciences, Lanzhou University, for his invaluable assistance and support.DAS:The datasets utilized for the bioinformatics analysis in our study are available from the TCGA database (https://www.cancer.gov/ccg/research/genome-sequencing/tcga).

语种：英文

外文关键词：Cancer; Tumor microenvironment; Histone lactylation; Glycolysis; Lipid metabolism

摘要：BackgroundThe complexity of cancer is intricately linked to its multifaceted biological processes, including the roles of the tumor microenvironment (TME) as well as genetic and metabolic regulation. Histone lactylation has recently emerged as a novel epigenetic modification mechanism that plays a pivotal role in regulating cancer initiation, proliferation, invasion, and metastasis.ObjectiveThis review aims to elucidate the role of histone lactylation in modulating various aspects of tumor biology, including DNA repair mechanisms, glycolytic metabolic abnormalities, functions of non-tumor cells in the TME, and the promotion of tumor inflammatory responses and immune escape. Additionally, the review explores potential therapeutic strategies targeting histone lactylation.MethodsA comprehensive literature review was performed, analyzing recent findings on histone lactylation and its impact on cancer biology. This involved a systematic examination of studies focusing on biochemical pathways, cellular interactions, and clinical implications related to histone lactylation.ResultsHistone lactylation was identified as a critical regulator of tumor cell DNA repair mechanisms and glycolytic metabolic abnormalities. It also significantly influences the functions of non-tumor cells within the TME, promoting tumor inflammatory responses and immune escape. Moreover, histone lactylation acts as a multifunctional biological signaling molecule impacting immune responses within the TME. Various cell types within the TME, including T cells and macrophages, were found to regulate tumor growth and immune escape mechanisms through lactylation.ConclusionHistone lactylation offers a novel perspective on tumor metabolism and its role in cancer development. It presents promising opportunities for the development of innovative cancer therapies. This review underscores the potential of histone lactylation as a therapeutic target, paving the way for new strategies in cancer treatment.