文献类型：期刊文献

中文题名：吉兰-巴雷综合征中补体与抗体协同致病机制及其免疫治疗的研究进展

英文题名：Recent advance in synergistic pathogenesis of complement and antibody in Guillain-Barrésyndrome and its immunotherapy

作者：薛育倩[1];刘爱玲[1];费成景[1];刘宇蕾[1];都明浩[1];张泽钰[1];尹榕[2]

第一作者：薛育倩

机构：[1]甘肃中医药大学第一临床医学院,兰州730000;[2]甘肃省中心医院神经内科,兰州730070

第一机构：甘肃中医药大学临床医学院

年份：2025

卷号：24

期号：9

起止页码：959

中文期刊名：中华神经医学杂志

外文期刊名：Chinese Journal of Neuromedicine

收录：;北大核心:【北大核心2023】；

基金：甘肃省重点人才项目(2025RCXM068)。

语种：中文

中文关键词：吉兰-巴雷综合征;补体;抗体;免疫治疗;协同致病机制

外文关键词：Guillain-Barrésyndrome;Complement;Antibody;Immunotherapy;Synergistic Pathogenesis

摘要：目前临床实践发现吉兰-巴雷综合征(GBS)患者体液中抗神经节苷脂抗体存在异质性,常规免疫治疗对部分GBS临床亚型的疗效有限。参考其他神经免疫疾病的治疗方案,针对抗体与补体系统的靶向调控已成为GBS治疗研究的重要方向。本文通过梳理补体、抗体及其相关炎性因子介导的免疫应答机制,探讨GBS免疫治疗领域的新策略,旨在为该病的个体化治疗提供理论依据和研究切入点。
Guillain-Barrésyndrome(GBS)is an autoimmune-mediated acute polyradiculoneuropathy.Its key feature is focal segmental demyelination along with inflammatory cell infiltration and axonal damage.In clinical practice,anti-ganglioside antibodies in the body fluid of GBS patients show heterogeneity,and conventional immunotherapy is ineffective in some GBS subtypes.Drawing on treatment options for other neuroimmune diseases,targeted regulation of antibody-complement system has now become an important direction in GBS treatment research.This paper examines the immune response mechanisms involving complement,antibodies and related inflammatory factors,explores new strategy in GBS immunotherapy,so as to provide theoretical basis and research entry points for GBS individualized treatment.