文献类型：期刊文献

英文题名：Advancements in Therapeutic Deep Eutectic Solvents as Multifunctional Transdermal Delivery Systems

作者：Li, Ke[1,2];Yan, Bo[1];Cao, Zhibo[1];Lu, Rongrong[1];Wu, Guotai[1];Hai, Yang[3]

第一作者：李楷

通信作者：Hai, Y[1]

机构：[1]Gansu Univ Chinese Med, Gansu Pharmaceut Ind Innovat Res Inst, Lanzhou 730101, Peoples R China;[2]Gansu Univ Chinese Med, Key Lab Chem & Qual, Lanzhou 730101, Peoples R China;[3]Gansu Univ Chinese Med, Res & Expt Ctr, Lanzhou 730101, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Res & Expt Ctr, Lanzhou 730101, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：18

期号：3

外文期刊名：PHARMACEUTICS

收录：;Scopus(收录号：2-s2.0-105034104175);WOS:【SCI-EXPANDED(收录号:WOS:001725390600001)】；

基金：This study received financial support from research grant from the National Natural Science Foundation of China (82505052) and the Gansu Provincial Department of Education (RQRY-2024-055, 2026QB-069). We are thankful for the grant from the Lanzhou Science and Technology Plan Project for 2024-QN-133.

语种：英文

外文关键词：therapeutic deep eutectic solvents (TheDES); transdermal drug delivery; stratum corneum; eutectogels; lipid exchange

摘要：The human skin, specifically the stratum corneum (SC), remains a formidable barrier to the delivery of therapeutic agents. Nearly 80% of new drug candidates exhibit poor solubility or low permeability, necessitating the development of novel delivery vehicles. Therapeutic deep eutectic solvents (TheDES) have emerged as a "green," multifunctional solution capable of significantly enhancing the solubility and transdermal flux of active pharmaceutical ingredients (APIs). This review discusses the physicochemical fundamentals of TheDES, mechanisms of permeation enhancement-including the newly identified "lipid exchange" effect-and the transition from liquid solvents to advanced dosage forms such as eutectogels and nanoemulsions. Current therapeutic applications in pain management, infectious diseases, and chronic conditions are highlighted, alongside critical assessments of dermatological safety and future directions in computational modeling.