文献类型：期刊文献

中文题名：MAPK/AMPK/mTOR信号通路在自噬中的作用机制研究进展

英文题名：Research progress on mechanisms of MAPK/AMPK/mTOR signaling pathways in autophagy

作者：唐强[1];彭冉东[2];张彦军[2];张宏艳[1];张德宏[1];刘伟[1];孙志鹏[1];毕军伟[2]

第一作者：唐强

机构：[1]甘肃中医药大学中医临床学院,甘肃兰州730030;[2]甘肃省中医院骨髓炎科,甘肃兰州730050

第一机构：甘肃中医药大学中医临床学院

年份：2025

卷号：65

期号：11

起止页码：153

中文期刊名：山东医药

外文期刊名：Shandong Medical Journal

基金：国家中医药管理局高水平重点学科(中医骨伤科学)建设项目[国中医药人教函(2023)85号];甘肃省中医药科研课题项目(GZKZ-2024-5,GZKG-2024-46);甘肃省科技计划联合科研基金项目(23JRRA1534);兰州市科技发展指导性计划项目(2020-ZD-31)。

语种：中文

中文关键词：自噬;丝裂原活化蛋白激酶;腺苷酸活化蛋白激酶;哺乳动物雷帕霉素靶蛋白;信号通路

外文关键词：autophagy;mitogen-activated protein kinase;adenylate kinase;mammalian target of rapamycin;signaling pathways

摘要：自噬是维持细胞稳态的重要过程,在能量代谢、细胞凋亡及多种疾病的发生发展中发挥关键作用。丝裂原活化蛋白激酶(MAPK)、腺苷酸活化蛋白激酶(AMPK)及哺乳动物雷帕霉素靶蛋白(mTOR)信号通路是调控自噬的三大核心通路,彼此之间存在复杂的交互与反馈调节。MAPK通路可通过ERK、JNK及p38等亚型双向调节自噬;AMPK作为能量感应激酶,在能量匮乏时通过抑制mTORC1或激活ULK1复合物促进自噬;而mTOR信号通路则主要作为负调控系统,通过mTORC1和mTORC2复合物在不同阶段抑制自噬的发生。MAPK、AMPK与mTOR信号网络在多种疾病中均发挥关键作用,包括肿瘤、代谢紊乱及心血管疾病等。深入阐明这些信号通路在自噬调控中的相互作用机制,将有助于揭示自噬在病理生理过程中的功能,并为相关疾病的精准干预提供理论依据和治疗策略。
Autophagy is a vital process for maintaining cellular homeostasis,playing a pivotal role in energy metabolism,apoptosis,and the development of various diseases.The mitogen-activated protein kinase(MAPK),adenosine monophosphate-activated protein kinase(AMPK),and mammalian target of rapamycin(mTOR)signaling pathways constitute three core regulatory networks governing autophagy,exhibiting intricate interactions and feedback regulation.The MAPK pathway bidirectionally regulates autophagy via its ERK,JNK,and p38 subunits;AMPK,as an energy-sensing ki nase,promotes autophagy during energy deprivation by inhibiting mTORC1 or activating the ULK1 complex;whereas the mTOR signaling pathway primarily functions as a negative regulatory system,inhibiting autophagy at different stages through the mTORC1 and mTORC2 complexes.The MAPK,AMPK,and mTOR signaling networks play pivotal roles in numerous diseases,including tumors,metabolic disorders,and cardiovascular diseases.Elucidating the interactive mechanisms of these pathways in autophagy regulation will shed light on autophagy's functional role in pathophysiological processes and provide theoretical foundations and therapeutic strategies for precision interventions in related diseases.