文献类型：期刊文献

中文题名：中药防治糖尿病胃轻瘫作用机制研究进展

英文题名：Mechanism of Chinese Medicine Against Diabetic Gastroparesis:A Review

作者：李龙[1];唐志锋[2];宋雯静[1];陈芳艺[1];岳雨婷[1];杨霞[3];王志刚[3];祝宛新[1];万生芳[1]

第一作者：李龙

机构：[1]甘肃中医药大学,兰州730000;[2]天水市中西医结合医院,甘肃天水741020;[3]天水市中医医院,甘肃天水741000

第一机构：甘肃中医药大学

年份：2024

卷号：30

期号：17

起止页码：256

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;Scopus;北大核心:【北大核心2023】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金项目(82060914);甘肃省中医药科研课题(GZKP-2021-46)。

语种：中文

中文关键词：糖尿病胃轻瘫;中医药;Cajal间质细胞;炎症反应;氧化应激;细胞焦亡;信号通路

外文关键词：diabetic gastroparesis;traditional Chinese medicine;Cajal interstitial cells;inflammatory response;oxidative stress;cellular pyroptosis;signaling pathways

摘要：糖尿病胃轻瘫是临床上常见的糖尿病相关的神经病变,影响了胃的正常运动和排空功能,临床上常可见其表现为腹胀、恶心呕吐、早饱感、消化不良等。糖尿病胃轻瘫的发病机制是多因素的,与长期高血糖、神经病变、自主神经系统紊乱、炎症、氧化应激等众多因素密切相关。这些因素可相互作用,导致胃排空延迟和相关症状的发生。中医药在防治糖尿病胃轻瘫中不仅具有历史悠久、疗效显著、个体化治疗、多元治疗剂型、改善生活质量的优势,并且具有低不良反应、耐受性好、多靶点起效等优点。因此,中医药在糖尿病胃轻瘫的防治中占据着重要地位。同时,既往研究发现,中药防治糖尿病胃轻瘫的主要作用机制包括调节胃肠激素、抑制炎症反应、减轻氧化应激、增强Cajal间质细胞活性、抑制细胞焦亡及调控干细胞因子(SCF)/细胞生长因子受体(c-Kit)、单磷酸腺苷活化蛋白激酶(AMPK)、Ras同源物基因组成员A(RhoA)/Rho蛋白相关卷曲螺旋激酶(ROCK)等相关信号通路等。该文主要总结了中药通过抑制炎症反应、减轻氧化应激、增强Cajal间质细胞活性、抑制细胞焦亡及调控相关信号通路防治糖尿病胃轻瘫的研究进展,旨在为进一步研究中药在糖尿病胃轻瘫防治中的应用价值提供参考和依据。
Diabetic gastroparesis(DGP)is a common diabetic neuropathy that affects the normal function of gastric motility and emptying.Clinically,it often manifests as abdominal distension,nausea and vomiting,early satiety,dyspepsia,etc.The pathogenesis of DGP is multifactorial,closely related to many factors,such as chronic hyperglycemia,neuropathy,autonomic nervous system disorders,inflammation,and oxidative stress.These factors can interact with each other,leading to delayed gastric emptying and the occurrence of related symptoms.Traditional Chinese medicine(TCM)has significant advantages in the prevention and treatment of DGP,including a long history,remarkable efficacy,individualized treatment,diverse therapeutic formulations,and improvement in the quality of life.Additionally,TCM is known for its low adverse reactions,good tolerance,and multi-targeted effects,making it an important approach in the management of DGP.Previous research has found that the main mechanisms of Chinese medicine in the prevention and treatment of DGP include the regulation of gastrointestinal hormones,inhibition of inflammatory responses,reduction of oxidative stress,enhancement of interstitial cells of Cajal activity,inhibition of pyroptosis,and modulation of related signaling pathways such as stem cell factor(SCF)/cellular growth factor receptor(c-Kit),adenosine monophosphate-activated protein kinase(AMPK),Ras homologous genome member A(RhoA)/Rho-associated coiled-coil forming kinase(ROCK).This article primarily summarized the research progress on Chinese medicine in preventing and treating DGP through the inhibition of inflammatory responses,reduction of oxidative stress,enhancement of interstitial cells of Cajal activity,inhibition of pyroptosis,and regulation of related signaling pathways,aiming to provide a reference and basis for further research on the application value of Chinese medicine in the prevention and treatment of DGP.