文献类型：期刊文献

英文题名：SESTD1 as a potential prognostic biomarker associated with tumor aggressiveness and immune infiltration in hepatocellular carcinoma

作者：Liu, Ying[1,2];Chen, Taoying[3];Tang, Li[4];Cheng, Daqing[5];Xu, Ming[5];Wu, Jiaoxiang[1];Liu, Bingyan[6];Cheng, Hao[7];Han, Bo[1,5];Zhang, Yu[8];Cheng, Sheng[1,5]

第一作者：刘莹;Liu, Ying

通信作者：Han, B[1];Cheng, S[1];Han, B[2];Cheng, S[2];Zhang, Y[3]

机构：[1]Shanghai Jiao Tong Univ, Tongren Hosp, Hongqiao Int Inst Med, Sch Med, Shanghai, Peoples R China;[2]Gansu Univ Chinese Med, Clin Coll Tradit Chinese Med, Lanzhou, Peoples R China;[3]Guiyang Univ, Sch Food Sci & Engn, Guiyang, Guizhou, Peoples R China;[4]Shanghai Jiao Tong Univ, Tongren Hosp, Sch Med, Rehabil Dept, Shanghai, Peoples R China;[5]Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Dept Gen Surg, Shanghai, Peoples R China;[6]Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Dept Intervent Radiol, Shanghai, Peoples R China;[7]Shanghai Huayang Community Hlth Ctr, Rehabil Dept, Shanghai, Peoples R China;[8]Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Dept Otorhinolaryngol, Shanghai, Peoples R China

第一机构：Shanghai Jiao Tong Univ, Tongren Hosp, Hongqiao Int Inst Med, Sch Med, Shanghai, Peoples R China

通信机构：[1]corresponding author), Shanghai Jiao Tong Univ, Tongren Hosp, Hongqiao Int Inst Med, Sch Med, Shanghai, Peoples R China;[2]corresponding author), Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Dept Gen Surg, Shanghai, Peoples R China;[3]corresponding author), Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Dept Otorhinolaryngol, Shanghai, Peoples R China.

年份：2025

卷号：80

外文期刊名：CLINICS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001585947800001)】；

基金：This work was supported by the National Natural Science Foundation of China (82002495), Research Fund of Shanghai Tongren Hospital (TRKYRC-xx202205, TRKYRC-xx202212, TRKYRC-xx202213), Fundamental Research Funds for the Central Universities (YG2025QNB53, YG2022QN117), and Research Fund of Key Laboratory for Translational Research and Innovative Therapeutics of Gastrointestinal Oncology (ZDSYS-2021-04).

语种：英文

外文关键词：SESTD1; Hepatocellular carcinoma; Diagnosis and prognosis; Proliferation and migration; Tumor immunity

摘要：Background: Hepatocellular Carcinoma (HCC) is one of the most prevalent forms of malignancies worldwide, with a low overall survival rate and limited treatments. SESTD1 is upregulated in a variety of cancers and may serve as a potential prognostic indicator and therapeutic target. However, the expression pattern and functional relevance of SESTD1 in HCC are still unknown. Methods: SESTD1 expression and its prognostic value in HCC were evaluated by parsing multiple databases, including the Cancer Genome Atlas (TCGA), GEO databases, and Kaplan-Meier (KM) plotter. Gene Ontology (GO) and Gene Set Enrichment Analysis (GSEA) were conducted to investigate the potential biological functions and regulatory pathways of SESTD1. The relationship between SESTD1 expression and immune-infiltration levels was investigated in the Tumor Immune Estimation Resource (TIMER). RT-qPCR and Western blot analysis of tumor tissues were performed to verify SESTD1expression in HCC. CCK8, colony formation, and transwell assays were used to evaluate the influence of SESTD1 on HCC cell proliferation and migration. Results: The authors identified significantly elevated SESTD1 expression in Hepatocellular Carcinoma (HCC) tissues, which is associated with poor patient prognosis. Functional enrichment analysis revealed that SESTD1 regulates cell proliferation and the cell cycle, and in vitro experiments validated that silencing SESTD1 suppresses HCC cell proliferation and metastasis. Mechanistically, SESTD1 appears to modulate immune cell infiltration within the tumor microenvironment and shows a positive correlation with the expression of immune checkpoint molecules PD-1 and PD-L1. Conclusion: SESTD1 may serve as a diagnostic and prognostic marker, as well as a potential target for immunotherapy in HCC.