文献类型：期刊文献

英文题名：Range of Molecular Weight of Different Effective Components in the Aqueous Extract of Angelica-Radix Hedysari Ultrafiltration Content by HPLC-MS

作者：Liu, Chaoqun[1];Du, Tao[2,3];Wang, Jia[4];Zhao, Xinke[3];Li, Yingdong[3];Liu, Kai[2]

第一作者：刘超群

通信作者：Liu, K[1]

机构：[1]Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Coll Integrated Tradit & Western Med, Lanzhou 730000, Peoples R China;[3]Cardiovasc Med Lanzhou Second Peoples Hosp, Lanzhou 730046, Peoples R China;[4]Ningxia Med Univ, Sch Basic Med Sci, Key Lab Fertil Preservat & Maintenance, Minist Educ, Yinchuan 750004, Peoples R China

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Integrated Tradit & Western Med, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：46

期号：5

起止页码：474

外文期刊名：JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001339487900007)】；

语种：英文

外文关键词：Aqueous extract of Angelica- Radix Hedysari; Water extraction ultrafiltration; HPLC-MS; HPLC; Saponins; Polysaccharide

摘要：The molecular weight range of effective components in the aqueous extract of Angelica- Radix Hedysari (1:5) was analyzed, providing a foundation for understanding its chemical composition and pharmacodynamics. Ultrafiltration technology was used to prepare different forms of the extract, including water extract powder, ultrafiltration powder, ultrafiltration saponin component powder, and ultrafiltration polysaccharide component powder. High-performance liquid chromatography-mass spectrometric (HPLC-MS) were used to analyze these extracts. Comparison between the components of Angelica- Radix Hedysari using HPLC and HPLC-MS showed that the ultrafiltration products contained fewer components than the original extract powder. However, the content of some components in the ultrafiltration products increased. The components with molecular weight greater than 10 kDa were removed during ultrafiltration, resulting in fewer components in the ultrafiltration products compared to Angelica Hongqi extract powder.