文献类型：期刊文献

中文题名：秦艽化学成分和药理作用研究进展及质量标志物(Q-marker)的预测分析

英文题名：Research progress on chemical constituents and pharmacological effects of Gentianae Macrophyllae Radix and quality markers(Q-marker) prediction and analysis

作者：杨飞霞[1];王玉[1];夏鹏飞[1,2,3];杨蕊菁[1];王玉霞[1];张建[1];樊秦[1];赵磊[1,2,3]

第一作者：杨飞霞

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃中医药大学甘肃省高校中藏药化学与质量研究省级重点实验室,甘肃兰州730000;[3]甘肃省道地药材质量标准化技术研究与推广工程实验室,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2020

卷号：51

期号：10

起止页码：2718

中文期刊名：中草药

外文期刊名：Chinese Traditional and Herbal Drugs

收录：CSTPCD;;Scopus;北大核心:【北大核心2017】；CSCD:【CSCD2019_2020】；

基金：国家自然科学基金资助项目(81660577);青海省藏药药理学和安全性评价研究重点实验室开发课题(2018-ZY-05);甘肃省道地药材质量标准化技术研究与推广工程实验室开放基金项目(ddyc-2016-04);甘肃省中医药管理局科研项目(G2K-2014-77)。

语种：中文

中文关键词：秦艽;质量标志物;质量评价;环烯醚萜;木脂素;抗炎;镇痛;保肝;抗病毒;抗肿瘤

外文关键词：Gentianae Macrophyllae Radix;quality markers;quality evaluation;iridoids;lignans;anti-inflammation;analgesic;liver protection;anti-virus;anti-tumor

摘要：秦艽是我国传统的中药材,功效独特且资源丰富,在我国西北地区分布较为广泛。秦艽中含有多种化学成分,主要有环烯醚萜类、木脂素类、黄酮类、三萜类、生物碱类等成分,具有抗炎镇痛、保肝、抗病毒、抗肿瘤、免疫抑制、降压等活性。由于其化学成分种类多样且药理活性广泛,可作为一种极具开发利用价值的药用植物。随着秦艽资源需求大增,野生秦艽资源极度萎缩,且秦艽药用基原众多、药用部位各异造成药材来源混杂,造成药用成分不稳定及市场混乱,质量标准亟待提高。在对秦艽资源现状、化学成分及药理作用分析的基础上,结合质量标志物的概念,从化学成分与传统药性、传统功效、临床疗效、不同配伍等多方面对秦艽质量标志物进行预测分析,为秦艽质量评价体系的建立提供参考。
Gentianae Macrophyllae Radix is a Chinese medicinal material with unique efficacy and rich resources, which is widely distributed in northwest China. Gentianae Macrophyllae Radix contains a variety of chemical components, including iridoids, lignans, flavonoids, triterpenes, alkaloids, and other components, with anti-inflammatory and analgesic, liver protection, anti-virus, anti-tumor, immunosuppression, antihypertensive and other activities. Because of its various chemical components and wide range of pharmacological activities, it can be used as a kind of medicinal plant with great development and utilization value. With the great increase in the demand for Gentianae Macrophyllae Radix resources, the wild Gentianae Macrophyllae Radix resources are extremely shrinking. There are many medicinal sources of Gentiana Macrophylla Radix, and the medicinal parts are different, resulting in mixed sources of Gentianae Macrophyllae Radix. Not only the medicinal ingredients are unstable, the market chaos is also very serious, and the quality standard needs to be improved urgently. Based on the analysis of the present situation of Gentianae Macrophyllae Radix resources, chemical composition and pharmacological action, combined with the concept of quality markers, the quality markers of Gentianae Macrophyllae Radix were predicted and analyzed from the aspects of chemical composition and traditional medicinal properties, traditional efficacy, clinical efficacy, different compatibility and so on, in order to provide reference for the establishment of quality evaluation system of Gentianae Macrophyllae Radix.