文献类型：期刊文献

英文题名：Protein kinase C: A potential therapeutic target for endothelial dysfunction in diabetes

作者：Xiao, Qian[1,2];Wang, Dan[1,2];Li, Danyang[2];Huang, Jing[1,2];Ma, Feifei[1,3];Zhang, Haocheng[1,4];Sheng, Yingda[1,2];Zhang, Caimei[1,2];Ha, Xiaoqin[1,2]

第一作者：Xiao, Qian

通信作者：Ha, X[1]

机构：[1]Chinese Peoples Liberat Army Joint Secur Force, Dept Lab, Forty Hosp 9, 333 Nanbinhe Middle Rd, Lanzhou 730050, Gansu, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Agr Univ, Coll Vet Med, Lanzhou 730070, Gansu, Peoples R China;[4]Lanzhou Univ, Sch Clin Med 2, Lanzhou 730030, Gansu, Peoples R China

第一机构：Chinese Peoples Liberat Army Joint Secur Force, Dept Lab, Forty Hosp 9, 333 Nanbinhe Middle Rd, Lanzhou 730050, Gansu, Peoples R China

通信机构：[1]corresponding author), Chinese Peoples Liberat Army Joint Secur Force, Dept Lab, Forty Hosp 9, 333 Nanbinhe Middle Rd, Lanzhou 730050, Gansu, Peoples R China.

年份：2023

卷号：37

期号：9

外文期刊名：JOURNAL OF DIABETES AND ITS COMPLICATIONS

收录：;Scopus(收录号：2-s2.0-85166521018);WOS:【SCI-EXPANDED(收录号:WOS:001051591500001)】；

基金：This research was supported by the National Natural Science Foundation of China (grant nos. 81273568).

语种：英文

外文关键词：Protein kinase C; Diabetes mellitus; Endothelial cell; Oxidative stress; Inflammation

摘要：Protein kinase C (PKC) is a family of serine/threonine protein kinases that play an important role in many organs and systems and whose activation contributes significantly to endothelial dysfunction in diabetes. The increase in diacylglycerol (DAG) under high glucose conditions mediates PKC activation and synthesis, which stimulates oxidative stress and inflammation, resulting in impaired endothelial cell function. This article reviews the contribution of PKC to the development of diabetes-related endothelial dysfunction and summarizes the drugs that inhibit PKC activation, with the aim of exploring therapeutic modalities that may alleviate endothelial dysfunction in diabetic patients.