文献类型：期刊文献

中文题名：针药并用对变应性鼻炎患者肺通气功能、IFN-γ水平及睡眠质量的影响

英文题名：Effect of acupuncture plus medication on the pulmonary ventilation, IFN-γ level and sleep quality in allergic rhinitis patients

作者：Luo, Hai-yan[1];Wei, Qing-lin[1];Tian, Yong-ping[1];Liu, Xiang-yi[2];Wang, Ya-nan[3];Zhang, Hai[3]

第一作者：雒海燕

通信作者：Luo, HY[1]

机构：[1]Gansu Univ Chinese Med, Acupuncture Clin Ctr, Affiliated Hosp, Lanzhou 730020, Peoples R China;[2]Gansu Univ Chinese Med, Basic Med Coll, Lanzhou 730020, Peoples R China;[3]Hexi Univ, Zhangye Peoples Hosp, Zhangye 734000, Peoples R China

第一机构：甘肃中医药大学第二附属医院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Acupuncture Clin Ctr, Affiliated Hosp, Lanzhou 730020, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2019

卷号：17

期号：6

起止页码：402

外文期刊名：JOURNAL OF ACUPUNCTURE AND TUINA SCIENCE

收录：Scopus(收录号：2-s2.0-85077081507);WOS:【ESCI(收录号:WOS:000511727900004)】；

语种：中文

外文关键词：Acupuncture Therapy; Acupuncture Medication Combined; Rhinitis; Allergic; Fluticasone Propionate; Nasal Sprays; Pulmonary Ventilation; Interferons; Sleep; R246; 8; A

摘要：Objective: To observe the effect of warm-unblocking acupuncture plus fluticasone propionate nasal spray on the pulmonary ventilation, level of interferon-gamma (IFN-gamma) and sleep quality in patients with allergic rhinitis (AR). Methods: A total of 112 AR patients were enrolled between January 2013 and August 2018 and were divided into an observation group and a control group by the random number table method, with 56 cases in each group. Patients in the observation group received warm-unblocking acupuncture plus fluticasone propionate nasal spray, and patients in the control group only received fluticasone propionate nasal spray. The nasal symptom score, pulmonary function indexes, the levels of IFN-gamma and interleukin (IL)-4 in serum, and sleep quality in the two groups were compared. Results: After treatment, the total effective rate in the observation group was higher than that in the control group (P<0.05). The nasal symptom score dropped in both groups after treatment (both P<0.05), and the score in the observation group was lower than that in the control group (P<0.05). The pulmonary ventilation indexes all increased significantly after treatment in the observation group (all P<0.05); the forced expiratory volume in 1 second (FEV1) to forced vital capacity (FVC) ratio (FEV1/FVC) and the forced expiratory flow at 50%, 75% and 25%-75% of the vital capacity (FEF50%, FEF75%, FEF25%-75%) increased after treatment in the control group (all P<0.05); the pulmonary ventilation indexes were higher in the observation group than those in the control group (all P<0.05). The level of IFN-y increased significantly after treatment in the two groups (both P<0.05) and the level of IL-4 dropped significantly (both P<0.05); the observation group had a higher IFN-gamma level (P<0.05) and a lower IL-4 level (P<0.05) compared with the control group. Regarding the Pittsburgh sleep quality index (PSQI), the scores of subjective sleep quality, habitual sleep efficiency and sleep disturbances and the general PSQI score decreased significantly after treatment in both groups (all P<0.05), and the scores in the observation group were significantly lower than those in the control group (all P<0.05). Conclusion: Warm-unblocking acupuncture plus fluticasone propionate nasal spray can effectively control the clinical symptoms and improve pulmonary function in the treatment of AR; this approach can regulate the levels of IFN-gamma and IL-4 towards the normal range in AR patients; it can also improve patient's sleep quality. This method can produce more significant efficacy than fluticasone propionate nasal spray used alone.