文献类型：期刊文献

英文题名：Protection of Angelica sinensis Volatile Oil on Focal Cerebral Ischemia-Reperfusion in Rats

作者：Luo, Huiying[1,2];Wang, Xiaopeng[3];Su, He[3];Zhu, Lijuan[1,2]

第一作者：罗慧英;Luo, Huiying

通信作者：Luo, HY[1]

机构：[1]Gansu Coll Tradit Chinese Med, Dept Pharmacol, Lanzhou 730000, Peoples R China;[2]Tradit Chinese Med Gansu Prov, Key Lab Pharmacol & Toxicol, Lanzhou 730000, Peoples R China;[3]Peoples Hosp Gansu Prov, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Coll Tradit Chinese Med, Dept Pharmacol, Av Dingxi 30, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2014

卷号：33

期号：5

起止页码：771

外文期刊名：LATIN AMERICAN JOURNAL OF PHARMACY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000340156300010)】；

语种：英文

外文关键词：Angelica sinensis; Focal cerebral ischemia-reperfusion; Protective effects; Volatile oil

摘要：The mechanism of ischemia-reperfusion injure is very complicated, oxygen free radicals, excitatory amino acids, calcium ion, and blood rheology may invoved in it. Angelica sinensis volatile oil (AVSO) contains important active substances in aromatic fractions. In our previous research we demonstrated that AVSO possess protective effects on culture cortical cells damaged by glutamate, the mechanism was involved with maintain the activities of antioxidant enzymes, maintaining mitochondria membrane potential (MMP), inhibiting Ca2+ influx, and increasing the expression of bcl-2 while suppressing the expression of bax, thus alleviate apoptosis and necrosis. In this study, a middle cerebral artery occlusion (MCA: O) model was built in rat to probe into the effects of AVSO on focal cerebral ischemia-reperfusion. After cerebral ischemia-reperfusion damage, rats showed neurological defect symptoms: the cerebral infarct volume rate increased, the activity of NOS and the content of NO, and MDA in serum increased, the activity of SOD and GSH-Px decreased, the water content in brain tissue and the permeability of cerebral vascular increased, and the blood rheology indexes became abnormal. AVSO could alleviate all these changes, it's basically behave in: decrease the neurologic deficit score and the cerebral infarct volume rate, decrease the water content in brain tissue and the permeability of cerebral vascular, decrease the activity of NOS, and the content of NO and MDA in serum, increase the activity of SOD and GSH-Px in serum, and improve the abnormal blood rheology indexes, indicating that AVSO possess protective effects on focal cerebral ischemia-reperfusion in rats.