文献类型：期刊文献

英文题名：Electrochemical study of oxidized hyaluronic acid grafted with aniline tetramer Bletilla striata polysaccharide hydrogel wound dressings

作者：Luo, Li[1];Wang, Xiaofei[2];Ma, Li[1];Wang, Kaibin[1];Ma, Jiandong[1];Zhao, Xiaoliang[1];Wang, Yonggang[1];Zhang, Jing[1];Wang, Cunjin[1];Zhang, Weijie[1]

第一作者：Luo, Li

通信作者：Zhang, WJ[1]

机构：[1]Lanzhou Univ Technol, Sch Life Sci & Engn, Pengjiaping Rd 36, Lanzhou City 730050, Gansu Province, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Lanzhou Petrochem Gen Hosp Gansu Prov, Affiliated Hosp 4, Lanzhou 730060, Gansu Province, Peoples R China

第一机构：Lanzhou Univ Technol, Sch Life Sci & Engn, Pengjiaping Rd 36, Lanzhou City 730050, Gansu Province, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ Technol, Sch Life Sci & Engn, Pengjiaping Rd 36, Lanzhou City 730050, Gansu Province, Peoples R China.

年份：2025

卷号：20

期号：1

外文期刊名：BIOINTERPHASES

收录：;EI(收录号：20250817926368);Scopus(收录号：2-s2.0-85218291466);WOS:【SCI-EXPANDED(收录号:WOS:001416152100001)】；

基金：We thank the Natural Science Foundation of China (No. 81560737, 32260231, and 31860250), Gansu Provincial Natural Science Fund (No. 23JRRA840), and Science and Technology Innovation Special Fund Project of Gansu Province, China (No. 2019ZX-05) for supporting this work.

语种：英文

摘要：Bletilla striata polysaccharide, also known as Bletilla gum, is a water-soluble polymeric viscous polysaccharide with antimicrobial and coagulation-promoting activities. This study used Bletilla striata polysaccharide as the base material and crosslinked it with an electroactive carrier material to prepare a hydrogel with both conductivity and bioactivity. Specifically, hydroxypropyl chitosan with good bioactivity was used as a cross-linking agent. Through Schiff base reaction, oxidized hyaluronic acid grafted with aniline tetramer copolymer and oxidized Bletilla striata polysaccharide were crosslinked to prepare conductive hydrogels, and their properties were characterized. Comparative results indicate that the oxidized Bletilla striata polysaccharide-hyaluronic acid conductive hydrogel (HP/OB-OT4) prepared with 20% grafted conductive polymer aniline tetramer content exhibits good conductivity, with an electrical conductivity reaching 0.32 +/- 0.013 mS/cm, meeting the requirements for microcurrent stimulation. It also shows a degradation rate of 58.46 +/- 1.96% and possesses good antibacterial properties and biocompatibility, demonstrating potential for application in biomedical material fields such as wound dressings.