文献类型：期刊文献

中文题名：天然化合物抗幽门螺杆菌的研究进展

英文题名：Research progress on natural compounds against Helicobacter pylori

作者：王振[1,2];张照杰[1,2];杨妹霞[1,2];张婷[1,2];张久聪[2]

第一作者：王振

机构：[1]甘肃中医药大学第一临床医学院,甘肃兰州730030;[2]中国人民解放军联勤保障部队第九四〇医院消化内科,甘肃兰州730050

第一机构：甘肃中医药大学临床医学院

年份：2026

卷号：43

期号：3

起止页码：210

中文期刊名：沈阳药科大学学报

外文期刊名：Journal of Shenyang Pharmaceutical University

基金：甘肃省卫生健康行业科研项目(GSWSKY2023-34);兰州市青年科技人才创新项目(2024-QN-39)。

语种：中文

中文关键词：幽门螺杆菌;天然化合物;抗幽门螺杆菌活性

外文关键词：Helicobacter pylori;natural compounds;anti-Helicobacter pylori activity

摘要：幽门螺杆菌(Helicobacter pylori,Hp)是一种主要定植于胃黏膜的革兰氏阴性菌,与胃炎、消化性溃疡及胃癌等疾病的发生密切相关。常用治疗方法包括含抗生素的三联或四联疗法,但长期应用易产生耐药性和药物不良反应。源于生物体代谢产生的天然化合物(如生物碱、萜类、黄酮、鞣质、香豆素、醌类等),因来源广泛、结构多样及较低的潜在毒性,在Hp的防治领域展现出显著优势和潜力。本文系统综述了上述天然化合物的主要来源及其抗Hp的作用机制,旨在为开发高效、低毒的新型抗Hp药物提供科学依据。
Helicobacter pylori(Hp)is a Gram-negative bacterium primarily colonizing the gastric mucosa.It is closely associated with the development of gastritis,peptic ulcers,and gastric cancer.Common therapeutic regimens include triple therapy and quadruple therapy;however,long-term application can lead to drug resistance and adverse drug reactions.Natural compounds derived from biological metabolism,such as alkaloids,terpenoids,flavonoids,tannins,coumarins,and quinones,demonstrate significant advantages and potential in the prevention and treatment of Hp infections,due to their wide natural sources,diverse structures,and relatively low potential toxicity.This article systematically reviews the sources of these natural compounds and their mechanisms of action against Hp,aiming to provide a scientific basis for developing novel,highly effective,and low-toxicity anti-Hp agents.