文献类型：期刊文献

中文题名：肠道菌群与骨质疏松的关系及中药调节研究进展

英文题名：Research Progress on Relationship Between Intestinal Flora and Osteoporosis and Regulation of Traditional Chinese Medicine:A Review

作者：钟建春[1];谢兴文[2,3];李鼎鹏[2,3];李宁[4];苏海霞[4];郭云龙[4]

第一作者：钟建春

机构：[1]甘肃省中医院,兰州730050;[2]甘肃省第二人民医院,兰州730030;[3]西北民族大学附属医院,兰州730030;[4]甘肃中医药大学,兰州730030

第一机构：甘肃省中医院,兰州730050

年份：2022

卷号：28

期号：18

起止页码：237

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：国家自然科学基金项目(82160911,81860864);中央引导地方科技发展专项项目-甘肃地区多发病防治能力提升创新平台;甘肃省青年科技基金计划项目(20JR5RA129);中央高校基本科研业务费项目(31920210041);敦煌医学与转化教育部重点实验室开放课题(DHYX19-05)。

语种：中文

中文关键词：肠-肾-骨骼;骨质疏松;肠道菌群;肾性骨病

外文关键词：gut-kidney-bone;osteoporosis;intestinal flora;renal osteopathy

摘要：随着我国老龄化程度的逐渐加重,骨质疏松患病率逐年增长,骨质疏松已成为威胁中老年人群,尤其中老年妇女健康的主要公共卫生问题。骨质疏松诱发因素众多且发病机制复杂,对骨质疏松的阐释一直是近年来临床研究的热点。如何更有效的防治骨质疏松亦成为研究者面临的重大难题。近年来肠道吸收、肾脏排泌和骨骼调控的钙、磷平衡和稳态成为研究的热点话题之一,而体内钙、磷平衡和稳态是正常骨稳态的关键。同时作为寄居在胃肠道的复杂微生物群落肠道菌群,能够产生多种影响代谢的调节物,间接或直接且多途径、多靶点作用于机体防治骨质疏松被广泛证实。因此,进一步探索肠-肾-骨骼轴在骨质疏松中的作用及机制对骨质疏松的防治起着深远的意义。近年来学者们运用中医药防治骨质疏松进行了大量探索,发现中医药能干预肠道菌群表达而起到防治骨质疏松的效果。该文从“肠-肾-骨骼轴”为基础出发,通过文献综述对肾与骨质疏松、肠与骨质疏松、肠-肾轴的中西医结合论述及从肠论治肾、肠与骨质疏松及中药调节肠道菌群在骨质疏松中的应用做简要论述,以期为骨质疏松的防治提供新的思路。
With the gradual aggravation of aging in China,the prevalence of osteoporosis is increasing year by year.Osteoporosis has become a major public health problem threatening the health of middle-aged and elderly people,especially middle-aged and elderly women.There are many predisposing factors and complex pathogenesis of osteoporosis.The interpretation of osteoporosis has been the focus of clinical research in recent years.How to prevent and treat osteoporosis more effectively has also become a major problem faced by researchers.In recent years,the balance and homeostasis of calcium and phosphorus regulated by intestinal absorption,renal excretion and bone have become one of the hot topics,and the balance and homeostasis of calcium and phosphorus in vivo are the key to normal bone homeostasis.At the same time,as a complex microbial community living in the gastrointestinal tract,intestinal flora can produce a variety of regulators affecting metabolism.It has been widely confirmed that it acts on the body indirectly or directly,in multiple ways and targets to prevent and treat osteoporosis.Therefore,further exploring the role and mechanism of intestine kidney bone axis in osteoporosis plays a far-reaching significance for the prevention and treatment of osteoporosis.In recent years,scholars have made a lot of exploration on the prevention and treatment of osteoporosis with traditional Chinese medicine(TCM),and found that TCM can intervene the expression of intestinal flora and play the effect of prevention and treatment of osteoporosis.Based on the "intestine kidney bone axis",this paper briefly discusses the integrated traditional Chinese and western medicine of kidney and osteoporosis,intestine and osteoporosis,intestine kidney axis,the treatment of kidney from intestine,intestine and osteoporosis,and the application of TCM in regulating intestinal flora in osteoporosis,in order to provide new ideas for the prevention and treatment of osteoporosis.