文献类型：期刊文献

英文题名：Progress in Research on Macrophage Polarization Mechanisms and Targeted Therapies in Staphylococcus aureus Infections

作者：Yan, Wentong[1];Li, Xupeng[1];Xu, Sen[1];Pan, Haibang[1,2];Wang, Bo[3];Zeng, Zhaoyang[2];Shi, Yuhong[2]

第一作者：Yan, Wentong

通信作者：Pan, HB[1]

机构：[1]Gansu Univ Chinese Med, Clin Coll 1, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Sch Nursing, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Clin Coll 1, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：18

起止页码：6655

外文期刊名：INFECTION AND DRUG RESISTANCE

收录：;Scopus(收录号：2-s2.0-105024824287);WOS:【SCI-EXPANDED(收录号:WOS:001642094800001)】；

基金：This study was supported by the National Natural Science Foundation of China (No. 82560941) , Gansu Provincial Key Talent Program (2025RCXM032) , Open Fund Project of Gansu Provincial Key Laboratory of Pharmacology and Toxicology of Traditional Chinese Medicine (ZDSYS-KJ-2024-008) , Gansu Provincial Higher Education Institution Faculty Innovation Fund Project (2025A-119) , Gansu Provincial Department of Science and Technology Natural Science Fund (24JRRA1024) , Gansu Provincial Department of Education Graduate Student "Innovation Star" Project (2025CXZX-948) , Gansu Provincial Department of Science and Technology Project (2023KCZD-13) ,Gansu Provincial Traditional Chinese Medicine Research Center Project (zyzx-2020-13) .

语种：英文

外文关键词：Staphylococcus aureus; macrophage polarization; immune regulation; drug-resistant infection; targeted therapy

摘要：Staphylococcus aureus is a clinically prevalent, Gram-positive pathogen that can cause multiple severe infections. Macrophage polarization plays a central role in host defense and inflammatory regulation, with its M1/M2 dynamic equilibrium directly determining infection outcomes. The M1 phenotype eliminates pathogens through pro-inflammatory responses in the early phase, but excessive activation readily leads to tissue damage. In contrast, the M2 phenotype suppresses inflammation and promotes healing during the repair phase, although it may become a pathogen refuge in chronic infections. Recent studies have elucidated the roles of PAMPs, virulence factors, immunometabolism, and epigenetics in regulating polarization and have explored intervention strategies involving stem cells, exosomes, nanodelivery, novel formulations, and natural medicines, offering new avenues to overcome antibiotic limitations. However, existing evidence remains confined to animal studies, and challenges related to polarization heterogeneity and clinical translation require urgent resolution. This review summarizes the mechanisms of macrophage polarization and targeted therapeutic advances in the context of S. aureus infection, aiming to provide insights for immune interventions against drug-resistant infections.