文献类型：期刊文献

中文题名：OPG/RANK/RANKL信号轴与原发性骨质疏松关系的研究进展

英文题名：Research progress of the relationship between OPG/RANK/RANKL signal axis and primary osteoporosis

作者：李应福[1];李宁[1];谢兴文[2]

第一作者：李应福

机构：[1]甘肃中医学院,兰州730000;[2]甘肃省中医院,兰州730050

第一机构：甘肃中医药大学

年份：2016

卷号：22

期号：1

起止页码：115

中文期刊名：中国骨质疏松杂志

外文期刊名：Chinese Journal of Osteoporosis

收录：CSTPCD;;北大核心:【北大核心2014】；CSCD:【CSCD2015_2016】；

语种：中文

中文关键词：原发性骨质疏松;细胞信号通路;破骨细胞;成骨细胞

外文关键词：Primary osteoporosis; Cell signal transduction; Osteoclast; Osteoblast

摘要：随着我国人口老龄化的逐渐加剧,原发性骨质疏松症的发病率日渐增加,这不仅会增加国家、社会的医疗投入,而且使人民的负担更加沉重。如何有效的预防、缓解甚或逆转原发性骨质疏松症病情的进展一直是生物医学研究的热点。因此更加深入的了解原发性骨质疏松症的发病机制与发展过程,为研发有效的药物提供理论支撑将尤为重要。近年来国内外研究的OPG/RANK/RANKL细胞信号通路就与原发性骨质疏松症的发生、发展存在着明显的相关性。本文旨在对此细胞通路的研究现状与其作用展开综述,以期对今后研究此细胞信号通路与原发性骨质疏松症的预防、缓解及治疗等方面的相关研究有所帮助。
With the increase of aging population in China, the incidence of primary osteoporosis is increasing, which not only increases the expense of medical care of the country and the society, but also increases the burden of people. How to prevent, to relieve, or to reverse the progress of osteoporosis has always been a hot spot in biomedical research. Therefore, it is important to understand the pathogenesis and the development of osteoporosis in order to provide a theoretical support for the development of drugs. In recent years, it has been reported that OPG/RANK/RANKL signaling pathway is obviously correlated with the occurrence and development of osteoporosis. This article reviews the current situation of this cellular pathway and its effect, in order to help future research in this signaling pathway and the prevention and treatment of osteoporosis.