文献类型：期刊文献

中文题名：骨性关节炎与2型糖尿病相关性的研究进展

英文题名：Advances in the study of the association between osteoarthritis and type 2 diabetes mellitus

作者：杨鑫[1];程晴灏[2];张福康[1];张壮壮[1];樊华[1];杨永泽[1];张安任[1];郭洪章[2]

第一作者：杨鑫

机构：[1]甘肃中医药大学第一临床医学院甘肃省人民医院,甘肃兰州730000;[2]甘肃省人民医院骨科四病区,甘肃兰州730000

第一机构：甘肃中医药大学临床医学院

年份：2024

卷号：37

期号：2

起止页码：295

中文期刊名：中国临床研究

外文期刊名：Chinese Journal of Clinical Research

收录：CSTPCD;;Scopus

基金：甘肃省自然科学基金(20JR10RA358)。

语种：中文

中文关键词：骨性关节炎;代谢综合征;2型糖尿病;氧化应激

外文关键词：Osteoarthritis;Metabolic syndrome;Type 2 diabetes mellitus;Oxidative stress

摘要：骨性关节炎(OA)是一种以软骨丢失,伴有骨肥大和硬化,以及滑膜炎症为特征的骨关节疾病。在过去很长一段时间内,慢性骨老化和机械应力被认为是导致该疾病的单一因素。然而,最近对OA的认识进展还突出了其他危险因素的参与,如2型糖尿病或血脂异常,目前这两者都囊括在代谢综合征(METS)中。高糖暴露对关节组织可表现出局部毒性,从而增加局部氧化应激、蛋白水解酶、细胞因子的产生和晚期糖基化产物(AGE)的聚集,进而加快OA进程。因此,本文将挖掘现有的证据表明OA和糖尿病之间的联系,从而解释糖尿病诱发的OA(代谢性OA)具体发病机制。
Osteoarthritis(OA)is a disease of bone and joint characterized by cartilage loss,bone hypertrophy,sclerosis,and synovial inflammation.Chronic bone aging and mechanical stress were considered as the single risk factors that caused the disease for a long time.However,recent advances in understanding OA have highlighted the involvement of other risk factors,such as type 2 diabetes mellitus or dyslipidemia,both of which are now included in the metabolic syndrome(METS).High glucose exposure can cause local toxicity to joint tissues,leading to increased local oxidative stress,protein hydrolases,cytokine production,and aggregation of advanced glycation end-products(AGEs),which in turn accelerates the process of OA.Therefore,this article aims to explore the existing evidence linking OA and diabetes mellitus,to explain the specific pathogenesis of metabolic OA induced by diabetes mellitus.