文献类型：期刊文献

英文题名：Aquaporins: a novel perspective in the treatment of lung diseases

作者：Wu, Mengyuan[1,2];Miao, Zhiming[1,2];Liu, Fuxian[1,2];Dai, Sichao[1,2];Li, Yangyang[1,2];Zhou, Ting[1,2,3];Zhuo, Qihong[1,2];Zhang, Huanhuan[1,2];Song, Zhangbo[1,2];Nie, Haiyi[1,2];Yong, Wenxing[4];Zhang, Liying[1,2,5];Liu, Yongqi[1,2,5,6]

第一作者：Wu, Mengyuan

通信作者：Zhang, LY[1];Liu, YQ[1];Zhang, LY[2];Liu, YQ[2];Zhang, LY[3];Liu, YQ[3];Liu, YQ[4]

机构：[1]Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis, Wulipu Campus,35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Prevent & Treatment Tradit Chinese Med Res Gansu C, Wulipu Campus,35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Expt & Training Teaching Ctr, Lanzhou, Peoples R China;[4]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China;[5]Gansu Univ Chinese Med, Coll Basic Med, Lanzhou, Peoples R China;[6]Gansu Univ Chinese Med, Key Lab Dunhuang Med & Transformat Prov & Minister, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis, Wulipu Campus,35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Prevent & Treatment Tradit Chinese Med Res Gansu C, Wulipu Campus,35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Coll Basic Med, Lanzhou, Peoples R China;[4]corresponding author), Gansu Univ Chinese Med, Key Lab Dunhuang Med & Transformat Prov & Minister, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;[107351d2d02a88e1f325f]甘肃中医药大学基础医学院（敦煌医学研究所）;

年份：2025

卷号：74

期号：1

外文期刊名：INFLAMMATION RESEARCH

收录：;Scopus(收录号：2-s2.0-105019801158);WOS:【SCI-EXPANDED(收录号:WOS:001603555200001)】；

基金：This work was supported by the National Natural Science Foundation of China (U23A20502), National Natural Science Foun-dation of China(82160868), Open Foundation of Key Laboratory of Dunhuang Medicine and Transformation (DHYX24-23), Outstanding Graduate Student Innovation Star Project(2025CXZX-902).

语种：英文

外文关键词：Aquaporins; ALI; Asthma; COPD; Lung cancer; Traditional Chinese medicine

摘要：BackgroundAquaporins (AQPs) are a class of channel proteins expressed on the cell membrane, responsible for facilitating the transport of water molecules and certain small solutes across the membrane. Their dysregulation is involved in the occurrence and progression of major lung diseases.FindingsWe systematically reviewed the expression and functional alterations of AQPs in acute lung injury (ALI), pneumonia, asthma, chronic obstructive pulmonary disease (COPD), pulmonary fibrosis (PF) and lung cancer, and integrated the potential molecular mechanisms. In addition, we examine the regulatory mechanisms of traditional Chinese medicine on lung AQPs, and summarizes the research progress of inhibitors and small molecular compounds that modulate AQPs in lung diseases.ImplicationsAQPs may serve as promising therapeutic targets for lung diseases. This review offers novel insights and a foundation for the diagnosis, treatment, and drug development of lung diseases, positioning AQPs as a potential tool in combating these conditions.