文献类型：期刊文献

中文题名：功能性消化不良与脑肠肽的研究进展

英文题名：Functional dyspepsia and brain-gut peptides

作者：毛兰芳[1];汪龙德[2];张宏伟[1];刘俊宏[2];杜晓娟[1];彭志恒[3]

第一作者：毛兰芳

机构：[1]甘肃中医学院中医临床学院;[2]甘肃中医学院附属医院脾胃病科;[3]兰州大学第二附属医院检验科

第一机构：甘肃中医药大学中医临床学院

年份：2015

卷号：0

期号：4

起止页码：570

中文期刊名：世界华人消化杂志

外文期刊名：World Chinese Journal of Digestology

收录：Scopus

基金：国家自然科学基金地区基金资助项目;No.81360540;甘肃省中医药管理局基金资助项目;Nos.GZK-2012-31;GZK-2013-29;甘肃省科技厅自然基金资助项目;No.1212RJZA088;甘肃省中药药理与毒理学重点实验室基金资助项目;No.ZDSYS-KJ-2013-003~~

语种：中文

中文关键词：功能性消化不良;脑肠轴;脑肠肽;研究进展

外文关键词：Functional dyspepsia;Brain-gut axis;Brain-gut peptide;Research progress

摘要：功能性消化不良(functional dyspepsia,FD)是临床常见的胃肠道动力疾病和消化内科多发病,FD的发病机制与多种因素有关,但目前尚未阐明其确切的病因及发病机制.FD属于典型的身心疾病,FD与精神心理因素相互作用的发病机制与脑肠轴的调节障碍有关,其主要包括中枢神经系统对异常刺激的处理和脑肠肽(brain-gut peptides,BGP)水平的异常.BGP是脑肠轴靶向作用的分子基础,脑肠轴通过脑肠互动作用调控相关BGP水平的变化,从而影响FD的发病.目前发现与FD相关的BGP有15余种,相关BGP多在下丘脑、延髓、脊髓、胃肠黏膜表达,本文从相关BGP的分泌及作用机制来阐明其水平变化与FD发病的关系.
Functional dyspepsia（FD） is a frequently occurring gastrointestinal disorder, but its etiology and pathogenesis are still unclear because it is associated with multiple factors. As a typically physical and psychological disease, the role of psychological factors in the pathogenesis of FD involves the brain-gut axis, mainly abnormal stimulation processing by the central nervous system and abnormal levels of brain-gut peptides. Brain-gut peptides are the molecular basis of the action of the brain-gut axis, and the brain-gut axis affects the occurrence of FD by regulating the levels of brain-gut peptides. So far, 15 brain-gut peptides associated with FD have been found, which are predominantly expressed in the hypothalamus, medulla oblongata, spinal cord and gastrointestinal mucosa. The aim of this study is to clarify the relationship between brain-gut peptide levels and the occurrence of FD based on brain-gut peptide in terms of their secretion and mechanisms of action.