文献类型：期刊文献

中文题名：补骨脂活性成分对骨质疏松相关信号通路影响的研究概况

英文题名：The study of the effect of the active ingredients of fructus psoraleae on the osteoporosis-related signal pathways

作者：刘小钰[1];宋敏[1];蒋林博[1];周灵通[1];董万涛[2];巩彦龙[1]

第一作者：刘小钰

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃中医药大学附属医院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2017

卷号：23

期号：6

起止页码：831

中文期刊名：中国骨质疏松杂志

外文期刊名：Chinese Journal of Osteoporosis

收录：CSTPCD;;北大核心:【北大核心2014】；CSCD:【CSCD2017_2018】；

基金：甘肃省自然科学基金计划(1506RJZA048);甘肃省中医药管理局项目(GZK-2016-17);甘肃省重点中医药现代制药工程研究院自立项目(YWW-2015049)

语种：中文

中文关键词：补骨脂活性成分;骨质疏松;信号通路

外文关键词：Active ingredients of fructus psoraleae; Osteoporosis; Signal pathway

摘要：骨质疏松症(osteoporosis,OP)随社会老龄化进程加速在全球的发病率呈逐渐增长的态势,且致残、致死率较高,临床治疗效果尚不满意。补骨脂作为目前中医药防治OP的研究热点,疗效显著,其活性成分能够干预骨代谢相关信号通路,促进成骨细胞的分化、增殖,抑制破骨细胞的形成,维持骨稳态。本文将从三个方面围绕骨质疏松相关信号通路,对补骨脂活性成分治疗OP的作用机制展开综述,为OP靶向治疗提供依据,为进一步研究和开发抗骨质疏松新药提供前景。
Osteoporosis（OP） presents a trend of gradual growth with the accelerated aging process in the society. It represents a high rate of disability and mortality,with dissatisfactory clinical treatment effect. Scurfpea fruit,as a hot spot for prevention and treatment of OP with traditional Chinese medicine,presents a significant remedy. Its active ingredient can interfere with the signal pathways of bone metabolism,promote the differentiation and proliferation of osteoblasts,inhibit the formation of osteoclasts,and maintain the bone homeostasis. This paper summarizes the functional mechanism of active ingredients of scurfpea fruit in the treatment of OP from three aspects on osteoporosis-related signal pathways,provides a basis for targeted treatment of OP,and offers the prospect for further research and development of anti-osteoporosis drugs.