文献类型：期刊文献

英文题名：Ferroptosis-A Novel Mechanism With Multifaceted Actions on Stroke

作者：Fang, Xiao-Ling[1];Ding, Shao-Yun[1];Du, Xiao-Zheng[1];Wang, Jin-Hai[2];Li, Xing-Lan[1]

第一作者：方晓丽

通信作者：Du, XZ[1];Wang, JH[2]

机构：[1]Gansu Univ Tradit Chinese Med, Coll Acupuncture & Massage, Lanzhou, Peoples R China;[2]Second Hosp Lanzhou Univ, Dept Tradit Chinese Med, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Coll Acupuncture & Massage, Lanzhou, Peoples R China;[2]corresponding author), Second Hosp Lanzhou Univ, Dept Tradit Chinese Med, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2022

卷号：13

外文期刊名：FRONTIERS IN NEUROLOGY

收录：;Scopus(收录号：2-s2.0-85128864101);WOS:【SCI-EXPANDED(收录号:WOS:000791573300001)】；

基金：X-LF: collected, sorted out the literature, completed the writing of the manuscript, and the drawing of pictures. J-HW and X-LL: provided financial support for this study. X-ZD and J-HW: reviewed and revised the manuscript. S-YD: helped and supported X-LF's work. All authors contributed to the article and approved the submitted version.

语种：英文

外文关键词：stroke; ferroptosis; iron overload; amino acid metabolism; lipid peroxidation; inflammation; autophagy; apoptosis

摘要：As a neurological disease with high morbidity, disability, and mortality, the pathological mechanism underlying stroke involves complex processes such as neuroinflammation, oxidative stress, apoptosis, autophagy, and excitotoxicity; but the related research on these molecular mechanisms has not been effectively applied in clinical practice. As a form of iron-dependent regulated cell death, ferroptosis was first discovered in the pathological process of cancer, but recent studies have shown that ferroptosis is closely related to the onset and development of stroke. Therefore, a deeper understanding of the relationship between ferroptosis and stroke may lead to more effective treatment strategies. Herein, we reviewed the mechanism(s) underlying the onset of ferroptosis in stroke, the potential role of ferroptosis in stroke, and the crosstalk between ferroptosis and other pathological mechanisms. This will further deepen our understanding of ferroptosis and provide new approaches to the treatment of stroke.