文献类型：期刊文献

中文题名：中医药通过调控Keap1/Nrf2信号通路对急性肺损伤氧化应激的保护作用

英文题名：Protective effects of traditional Chinese medicine against oxidative stress in acute lung injury by modulating Keap1/Nrf2 signal pathway

作者：郝国雄[1];靳晓杰[1];徐倩[1];万家宜[1];梁夏丽[1];张丽敏[2];张志明[2]

第一作者：郝国雄

机构：[1]甘肃中医药大学甘肃省高校重大疾病分子医学与中医药防治研究重点实验室,甘肃兰州730000;[2]甘肃省中医院肿瘤科,甘肃兰州730000

第一机构：甘肃中医药大学科研实验中心（甘肃省中医药标准化技术委员会秘书处）

年份：2025

卷号：41

期号：5

起止页码：727

中文期刊名：中国临床药理学杂志

外文期刊名：The Chinese Journal of Clinical Pharmacology

收录：;北大核心:【北大核心2023】；

基金：甘肃省自然科学基金资助项目(23JRRA1241);甘肃省科技计划重大专项基金资助项目(甘科计[2022]1号-25);兰州市人才创新创业基金资助项目(2021-RC-80);兰州市科技计划基金资助项目(2023-2-91)。

语种：中文

中文关键词：中医药;急性肺损伤;Kelch环氧氯丙烷相关蛋白1/核因子E2相关因子2;氧化应激

外文关键词：Chinese medicine;acute lung injury;Kelch-like ECH associated protein 1/nuclear factor-E2-related factor 2;oxidative stress

摘要：急性肺损伤(ALI)/急性呼吸窘迫综合征是以肺血管通透性增加、炎性细胞浸润、肺水肿、弥漫性肺泡损伤和呼吸量减少为特征的危及生命的急性弥漫性肺部炎症损伤。ALI的发病机制复杂,而氧化应激是导致肺泡上皮细胞功能障碍,加剧ALI的关键机制。Kelch环氧氯丙烷相关蛋白1/核因子E2相关因子2(Keap1/Nrf2)信号通路是中医药通过调控氧化应激治疗ALI的重要信号通路。本文通过对治疗ALI的相关中药复方、活性成分进行分析、总结,发现大量抗氧化活性成分可以通过Keap1/Nrf2信号通路调控氧化应激,发挥改善ALI的作用,这也为ALI疾病的防治以及进一步的药物开发提供了依据。
Objective Acute lung injury(ALI)/acute respiratory distress syndrome is a life-threatening acute diffuse inflammatory lung injury characterised by increased pulmonary vascular permeability,inflammatory cell infiltration,pulmonary oedema,diffuse alveolar damage and reduced respiratory output.Its pathogenesis is complex,and oxidative stress is a key mechanism leading to ALI exacerbated by alveolar epithelial cell dysfunction.The Kelch-like ECH associated protein 1/nuclear factor-E2-related factor 2(Keap1/Nrf2)signalling pathway is an important signalling pathway of traditional Chinese medicine in the treatment of ALI by regulating oxidative stress.This paper analyses and summarizes the relevant Chinese medicine formulas and active ingredients for the treatment of ALI,and finds that a large number of antioxidant active ingredients can regulate oxidative stress through the Keap1/Nrf2 signaling pathway and play a role in improving ALI,which also provides a basis for the prevention and treatment of ALI disease and further drug development.