文献类型：期刊文献

中文题名：当归药材安全性的灰色关联度评价

英文题名：Safety Evaluation of Angelicae Sinensis Radix by Grey Incidence Degree Method

作者：顾志荣[1,2];陈晖[2];王亚丽[1,2];孙宇靖[2];丁军霞[1,2];张亚亚[1,2]

第一作者：顾志荣

机构：[1]甘肃中医学院药学院,兰州730000;[2]甘肃中医学院当归研究所,兰州730000

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2014

卷号：20

期号：17

起止页码：60

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2011】；

基金：国家自然科学基金项目(30960037);甘肃省发改委战略新兴产业和产业技术研究与开发专项(2011)

语种：中文

中文关键词：当归;安全性评价;灰色关联度法

外文关键词：Angelicae Sinensis Radix; safety evaluation; grey incidence degree method

摘要：目的：建立当归药材安全性的灰色关联度模型并进行安全性评价。方法：测定不同产地当归药材中总灰分、酸不溶性灰分以及铅、镉、砷、汞、铜5种有害重金属元素含量,以定义的相对关联度为测度,采用DPS V 7.0.5统计软件构建当归药材安全性的灰色关联度评价模型。结果：各评价单元序列的相对关联度在0.380 5～0.600 0,相对关联度〈0.500 0的样本共有25批,这些样本的安全性较好,主要是甘肃岷县、渭源县、漳县以及云南所产的当归样本;相对关联度排名在前25名的样本中,甘肃岷县产有9批,甘肃渭源县产有3批,甘肃漳县产有3批,云南产有4批,分别占各自产地样本总数的90.0%,50.0%,60.0%,100%;通过该模型得到的结论与当归药材的道地性内涵相一致。结论：该方法及模型可推广应用于当归药材的安全性评价。
Objective： The study was conducted to establish the method of degree incidence and to evaluate the safety of Angelicae Sinensis Radix from different habitats. Method： The contents of total ash,acid insoluble ash,Pb,Cd,As,Hg,and Cu in Angelicae Sinensis Radix were determined. The grey model was established by DPS V7. 0. 5 statistical software via the measurement of relative incidence degree. Result： The relative incidence degrees of all evaluation items were between 0. 380 5-0. 600 0; totally the relative incidence degrees from 25 batches of Angelicae Sinensis Radix were less than 0. 500 0,which had better safety,including 9batches from Min County,Gansu Province,3 batches from Weiyuan County,Gansu Province,3 batches from Zhang County,Gansu Province,and 4 batches from Yunnan Province,accounting for 90. 0%,50. 0%,60. 0%,and 100% of the total number of their samples,respectively. The results based on the established model showed that the evaluation results were consistent with the genuineness meaning of Angelicae Sinensis Radix. Conclusion：This method and model can be well used to evaluate the safety of Angelicae Sinensis Radix.