文献类型：期刊文献

中文题名：磷脂酰肌醇-3激酶/蛋白激酶B通路在骨关节炎的作用

英文题名：Role of phosphatidylinositol 3-kinase/protein kinase B pathway in osteoarthritis

作者：刘健[1,2];李嘉欢[1];张凯[1];谭飞[1];王静[1];邓泽群[3];林志强[1];周胜虎[2]

第一作者：刘健

机构：[1]甘肃中医药大学第一临床医学院,兰州730000;[2]解放军联勤保障部队第九四〇医院关节外科,兰州730050;[3]宁夏医科大学,银川750004

第一机构：甘肃中医药大学临床医学院

年份：2024

卷号：18

期号：6

起止页码：759

中文期刊名：中华关节外科杂志(电子版)

外文期刊名：Chinese Journal of Joint Surgery(Electronic Edition)

收录：CSCD:【CSCD2023_2024】；

基金：兰州市科技计划项目(2023-2-11);甘肃中医药大学导师专项(2023YXKY015)

语种：中文

中文关键词：骨关节炎;信号传导;综述

外文关键词：Osteoarthritis;Signal transduction;Review

摘要：骨关节炎(OA)是中老年人群常见的骨科疾病之一,给患者生活质量带来严重影响,其病因及病理学机制尚不明确,目前尚无有效防治措施,因此深入研究骨关节炎的发病机制具有重要意义。磷脂酰肌醇-3激酶(PI3K)/蛋白激酶B(AKT)信号通路是一种重要的细胞活动的信号通路,并通过AKT作用于多种类型的下游因子,参与正常细胞和肿瘤细胞代谢、生长、自噬、凋亡和血管生成等。近年研究发现PI3K/AKT信号通路与OA的发生发展密切相关。因此,有必要就PI3K/AKT信号通路与OA的关系进行综述,探讨此信号通路在OA治疗中的意义。
Osteoarthritis is one of the common orthopedic diseases in the middle-aged and elderly people,which has a serious effect on the quality of life of the patient,the pathogenesis of the disease is not clear,there is no effective cure measures,so further study of the pathogenesis of osteoarthritis is of great significance.phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway,an important signaling pathway of cellular activity impacts a variety of downstream factors through AKT,which is involved in the cell metabolism,growth,autophagy,apoptosis,and angiogenesis in normal and tumor cells.Recent studies have found that PI3K/AKT signaling pathway is closely related to the occurrence and development of OA.Therefore,it is necessary to review the relationship between PI3K/AKT signaling pathway and OA,and explore the significance of this signaling pathway in OA treatment.