文献类型：期刊文献

英文题名：A Novel Electrochemical Sensor Based on Conductive Cu₃(HITP)₂/electrochemical Reduced Graphene Oxide Nanocomposite for Simultaneous Determination of Dopamine and Acetaminophen

作者：Li, Shanshan[1];Dai, Hongxia[1,2,3];Chen, Hui[1];Zhang, Jian[1];Shi, Xiaoning[1];Zhang, Haobo[1]

第一作者：Li, Shanshan

通信作者：Dai, HX[1];Zhang, J[1];Dai, HX[2];Dai, HX[3]

机构：[1]Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China;[2]Northwest Collaborat Innovat Ctr Tradit Chinese M, Lanzhou, Peoples R China;[3]MOE, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China;[2]corresponding author), Northwest Collaborat Innovat Ctr Tradit Chinese M, Lanzhou, Peoples R China;[3]corresponding author), MOE, Lanzhou 730000, Peoples R China.|[1073501e14fb35863569f]甘肃中医药大学药学院（西北中藏药协同创新中心办公室）;[10735]甘肃中医药大学;

年份：2022

卷号：17

期号：12

外文期刊名：INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000981500600015)】；

基金：This work was supported by the National Natural Science Foundation of China (No. 21562001), the Educational Science and Technology Innovation Program of Gansu Province (No. 2021CYZC-13), the Natural Science Foundation of Gansu Province (No. 20JR10RA328), and the Young and Middle-aged Research Fund Project of Gansu University of Chinese Medicine (No. ZQ2017-11).

语种：英文

外文关键词：Cu-3(HITP)(2); Electrochemical reduced graphene oxide; Electrochemical sensor; Dopamine; Acetaminophen

摘要：Monitoring small amount of dopamine (DA) and acetaminophen (ACOP) in biological samples is of great significance for the early prevention of neurological diseases and safe use of medicines in clinical research. A novel electrochemical sensor based on conductive metal organic framework Cu-3(HITP) (2) (HITP=2,3,6,7,10,11-hexaiminotriphenylene) and electrochemical reduced graphene oxide nanocomposite (denoted as Cu-3(HITP)(2)/ERGO) was designed for simultaneous determination of DA and ACOP with enhanced sensitivity and selectivity. The Cu-3(HITP)(2)/ERGO nanocomposite was characterized by scanning electron microcopy, energy dispersive spectroscopy and Fourier infrared spectroscopy. The oxidation potential separation of DA and ACOP achieved 226 mV. The Cu-3(HITP)(2)/ERGO/GCE exhibited excellent electrochemical response towards the oxidation of DA and ACOP due to the superior conductivity and synergistic catalytic activity of Cu-3(HITP)(2)/ERGO nanocomposite. The detection limits were 9 nM and 14 nM (S/N=3) for DA and ACOP with wide linear range of 0.05-150 mu M and 0.1-100 mu M, respectively. Furthermore, the proposed sensor has been successfully applied in the simultaneous detection of DA and ACOP in serum sample.