文献类型：期刊文献

中文题名：骨髓干细胞移植对急性心肌梗死心功能影响的meta分析

英文题名：Bone marrow stem cell transplantation for acute myocardial infarction:a meta-analysis

作者：贾佳[1];晏丽[2];胡继宏[1]

第一作者：贾佳

机构：[1]甘肃中医学院,兰州730000;[2]兰州市卫生学校

第一机构：甘肃中医药大学

年份：2015

卷号：31

期号：5

起止页码：524

中文期刊名：临床心血管病杂志

外文期刊名：Journal of Clinical Cardiology

收录：CSTPCD;;北大核心:【北大核心2014】；CSCD:【CSCD_E2015_2016】；

语种：中文

中文关键词：心肌梗死;细胞移植;左射血分数;梗死面积

外文关键词：myocardial infarction; cell transplantation; left ejection fraction; infarct size

摘要：目的：探讨骨髓干细胞移植治疗急性心肌梗死心功能的效果。方法：系统检索数据库MEDLINE、EMBASE、Cochrane图书馆、中国知网以及万方数据库。时间为建库到2014年1月。纳入文献用RevMan5.2进行分析。结果：共4篇临床试验（n=218）纳入meta分析。结果显示：与对照组相比,骨髓干细胞移植显著提高了急性心肌梗死患者的左室射血分数（SMD=0.84,95%CI：0.12～1.55,P〈0.05）。而移植骨髓干细胞后的心肌梗死面积与注射无干细胞溶液的对照组相比,差异无统计学意义。结论：骨髓干细胞可改善急性心肌梗死后的左室射血分数。
Objective：To review the quality of climcal trials and lurther to evatuate the ettectlveness on acute myocardial infarction using bone marrow stem cell transplantation with meta-analysis. Method： We searched MEDLINE database, EMBASE database, Cochrane Library, Chinese HowNet database and Wanfang Medical Da- ta System which deadlined to January 2014, then assessed the quality of study literatures according to the Jadad score ratings and analyzed with RevMan5.2 statistical software. Result： A total of 4 literatures including 218 patients met the inclusion criteria. Meta-analysis showed that the left ejection fraction in the intervention group using bone marrow stem cell transplantation treatment was significantly higher than that in the control group （SMD= 0.84, 95% CI：0.12-1.55, P〈0.05）. But the size of myocardial infarction was not significantly different between two groups. Conclusion：Transplantation of bone marrow stem ceils can improve left ejection fraction.