文献类型：期刊文献

英文题名：Glucolipid metabolic dysfunction in ankylosing spondylitis: inflammatory mechanisms, immune-metabolic crosstalk and therapeutic implications of natural products and traditional Chinese medicine

作者：Dong, Xiaofei[1];Zhang, Jingjing[1];Chen, Zixuan[1];Liang, Yeqi[2];Chen, Yi[1];Xiao, Zheng[1];Li, Yingcun[1,3];Li, Ke[2,4]

第一作者：Dong, Xiaofei

通信作者：Li, YC[1];Li, K[2];Li, YC[3];Li, K[4]

机构：[1]Gansu Univ Chinese Med, Dept Basic Med Sci, Lanzhou, Gansu, Peoples R China;[2]Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China;[3]Dunhuang Med Literature Compilat & Applicat Res Ct, Gansu Prov Key Res Base Humanities & Social Sci, Lanzhou, Peoples R China;[4]Qujing Hosp Tradit Chinese Med, Dept Encephalopathy, Qujing, Peoples R China

第一机构：甘肃中医药大学基础医学院（敦煌医学研究所）

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Dept Basic Med Sci, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China;[3]corresponding author), Dunhuang Med Literature Compilat & Applicat Res Ct, Gansu Prov Key Res Base Humanities & Social Sci, Lanzhou, Peoples R China;[4]corresponding author), Qujing Hosp Tradit Chinese Med, Dept Encephalopathy, Qujing, Peoples R China.|[107351d2d02a88e1f325f]甘肃中医药大学基础医学院（敦煌医学研究所）;[10735]甘肃中医药大学;

年份：2026

卷号：17

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001856025000001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. This work was supported by the National Natural Science Foundation of China (No. 82174285); Dunhuang Medical Literature Collation and Application Research Center Project, Key Research Base of Humanities and Social Sciences in Universities of Gansu Province (No. DHYXJD2025); National Social Science Fund of China (No. 22BYY038); Education Department of Gansu Province: "Innovation Star" Project for Excellent Graduate Students (No. 2026CXCY-006); Clinical Research Project of Guangdong Provincial Hospital of Chinese Medicine, Grant No. YN10101905.

语种：英文

外文关键词：ankylosing spondylitis; cytokine; glucolipid metabolism; immune; inflammation

摘要：Ankylosing spondylitis (AS) is increasingly recognized as a systemic inflammatory disease accompanied by substantial glucolipid metabolic disturbances and an elevated risk of diabetes. Beyond articular inflammation, persistent immune activation reshapes metabolic homeostasis through interconnected mechanisms involving chronic cytokine signaling, immune-cell metabolic reprogramming, gut microbiota dysbiosis and endocrine disruption. Key mediators, including TNF-alpha, IL-6 and IL-17, promote insulin resistance, lipid abnormalities and endothelial dysfunction, while Th17/Treg imbalance, neutrophil activation and microbial metabolite alterations further amplify metabolic injury. These pathogenic interactions establish a self-reinforcing cycle in which inflammation and metabolic dysfunction mutually exacerbate one another. Emerging evidence also indicates that anti-inflammatory therapies, nutritional strategies and metabolic modulators may provide dual benefits by controlling disease activity while improving metabolic outcomes. This review summarizes the mechanistic links between AS and glucolipid dysregulation and highlights integrated therapeutic strategies, including pharmacological interventions, nutritional approaches, and natural products/traditional Chinese medicine, for reducing diabetes risk and improving long-term prognosis in AS.