文献类型：期刊文献

中文题名：基于“方药量-效关系”研究大黄黄连泻心汤治疗糖尿病

英文题名：Study of Dahuang Huanglian Xiexin Decoction in Treating Diabetes Based on“Dose-effectRelationship of Prescriptions”

作者：杨霞[1,2];梁永林[2];王志刚[1];柳荣[2];赵怡坤[2];周琦[2]

第一作者：杨霞

机构：[1]天水市中医医院,甘肃天水741000;[2]甘肃中医药大学,甘肃兰州730000

第一机构：天水市中医医院,甘肃天水741000

年份：2023

卷号：46

期号：1

起止页码：40

中文期刊名：陕西中医药大学学报

外文期刊名：Journal of Shaanxi University of Chinese Medicine

基金：甘肃省中医药综合防治重大疑难疾病科技攻关项目(GZKZD-2018-01);甘肃省产业支撑计划项目(2021CYZC-03)。

语种：中文

中文关键词：大黄黄连泻心汤;方药量-效关系;糖尿病

外文关键词：Dahuang Huanglian Xiexin Decoction;Dose-effect relationship of prescriptions;Diabetes

摘要：通过对大黄黄连泻心汤的药效物质基础及临床作用机制研究,发现大黄黄连泻心汤及其单味中药大黄、黄连、黄芩对糖尿病及其并发症均有一定的防治作用,可以显著改善胰岛素抵抗,具有降血糖、调血脂的功效,且可拮抗胰岛β细胞的损伤,促进β细胞再生及功能恢复,促进胰岛素的分泌。“中医不传之秘在于量”,方药剂量直接影响中医药临床疗效,由相同的药物组成的方剂,因剂量的不同而作用悬殊;单味中药在方中因剂量不同而发挥的作用差别也很大。大黄黄连泻心汤基于“方药量-效关系”治疗糖尿病的研究时,药物的用量与其在方中的功效具有密切相关性。
Through the research on the material basis and clinical mechanism of the efficacy of Dahuang Huanglian Xiexin Decoction,it is found that Dahuang Huanglian Xiexin Decoction and its single herbs,Rhubarb,Coptis chinensis and Scutellaria baicalensis Georgi,have certain preventive and therapeutic effects on diabetes and its complications,can significantly improve insulin resistance,have the effects of lowering blood sugar and regulating blood lipids,and can antagonize islets of langerhansβcell damage,promotingβcell regeneration and functional recovery,promote insulin secretion.“The secret of Chinese medicine lies in the dosage”.The dosage of a prescription directly affects the clinical efficacy of Chinese medicine.Formulas composed of the same drugs have different effects due to different doses;The effect of single Chinese medicine in the formula varies greatly due to different doses.When Dahuang Huanglian Xiexin Decoction is used to treat diabetes based on the study of“prescription dose effect relationship”,the dosage of the drug is closely related to its efficacy in the prescription.