文献类型：期刊文献

英文题名：GSTP1 rs4147581 C>G and NLRP3 rs3806265 T>C as Risk Factors for Chronic Obstructive Pulmonary Disease: A Case-Control Study

作者：Li, Honge[1];Wang, Raorao[1];Wei, Xueyan[1];Zhang, Chunyan[1];Pei, Wenhui[1];Zhang, Xuhui[2];Yang, Zhen[1];Li, Zhi[3];Zhang, Yuhuan[1];Shi, Yanli[1];Wang, Yunchao[4];Wang, Xinhua[1]

第一作者：Li, Honge

通信作者：Wang, XH[1];Wang, YC[2]

机构：[1]Gansu Univ Chinese Med, Inst Publ Hlth, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Dept Resp Med, Lanzhou, Gansu, Peoples R China;[3]Guangzhou Med Univ, Affiliated Hosp 1, Inst Publ Hlth, State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China;[4]Gansu Univ Chinese Med, Inst Basic Med, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Inst Publ Hlth, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Inst Basic Med, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：19

起止页码：489

外文期刊名：INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

收录：;Scopus(收录号：2-s2.0-85185675028);WOS:【SCI-EXPANDED(收录号:WOS:001171263800001)】；

基金：This study was supported by the following grants: National Key Research and Development Project of China 2017YFC0907202 (Xinhua Wang) ; National Natural Science Foundation of China (82260889) (Xuhui Zhang) ; Central Guided Local Science and Technology Development Funds Project No.22ZY1QA003 (Xinhua Wang) ; 2022 Gansu Province Higher Education Institutions Industry Support Program Project No.2022CYZC-53 (Xinhua Wang) .

语种：英文

外文关键词：chronic obstructive pulmonary disease; GSTP1; NLRP3; polymorphism

摘要：Background: Chronic obstructive pulmonary disease (COPD) is a chronic respiratory ailment influenced by a blend of genetic and environmental factors. Inflammatory response and an imbalance in oxidative-antioxidant mechanisms constitute the primary pathogenesis of COPD. Glutathione S-transferase P1(GSTP1) plays a pivotal role as an antioxidant enzyme in regulating oxidative-antioxidant responses in the pulmonary system. The activation of the NOD-like receptor thermal protein domain (NLRP3) inflammatory vesicle can trigger an inflammatory response. Several investigations have implicated GSTP1 and NLRP3 in the progression of COPD; nonetheless, there remains debate regarding this mechanism. Methods: Employing a case-control study design, 312 individuals diagnosed with COPD and 314 healthy controls were recruited from Gansu Province to evaluate the correlation between GSTP1 (rs4147581C>G and rs1695A>G) and NLRP3 (rs3806265T>C and rs10754558G>C) polymorphisms and the susceptibility to COPD. Results: The presence of the GSTP1 rs4147581G allele substantially elevated the susceptibility to COPD (CGvs.CC:OR=3.11,95% P<0.001). Similarly, the NLRP3rs3806265T allele significantly increased the susceptibility to COPD (TC:TT:OR=0.432,95% CI=0.296-0.630; TC+CCvs.TT:OR=2.132,95% CI=1.479-3.074, P<0.001). However, no statistically significant association was discerned between the rs1695A>G and rs10754558G>C polymorphisms and COPD susceptibility (P>0.05). Conclusion: In summary, this study ascertained that the GSTP1 rs4147581C>G polymorphism is associated with increased COPD susceptibility, with the G allele elevating the risk of COPD. Similarly, the NLRP3 rs3806265T>C polymorphism is linked to elevated COPD susceptibility, with the T allele heightening the risk of COPD.