文献类型：期刊文献

英文题名：The role of lactate and lactylation in ischemic stroke

作者：Wei, Mai[1];Liu, Cui[1];Jing, Weiyao[2];Liu, Qianru[1];Wei, Long[1];Li, Xing[1];Wang, Jinhai[3];Du, Xiaozheng[1]

第一作者：魏敏

通信作者：Wang, JH[1];Du, XZ[1]

机构：[1]Gansu Univ Chinese Med, Coll Acupuncture & Tuina, Lanzhou, Peoples R China;[2]Weifang Hosp Tradit Chinese Med, Weifang, Peoples R China;[3]Lanzhou Univ, Hosp 2, Dept Tradit Chinese Med, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Lanzhou Univ, Coll Acupuncture & Tuina, Hosp 2,Dept Tradit Chinese Med, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：165

外文期刊名：INTERNATIONAL IMMUNOPHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-105015463242);WOS:【SCI-EXPANDED(收录号:WOS:001571791600001)】；

基金：This work was supported by the National Natural Science Foundation of China (No.82460965) ,the National Natural Science Foundation of China (No.82260962) ,Gansu Province Key Traditional Chinese Medicine Research Project (GZKZ-2024-35) .

语种：英文

外文关键词：Ischemic stroke; Lactate; Epigenetics; Lactylation modifications

摘要：Stroke is a leading cause of death and disability worldwide. Ischemic cell death resulting from inadequate blood oxygen and glucose supply is one of the main pathophysiological mechanisms of brain injury. Previous studies have highlighted the critical role of lactate in the physiological and pathological processes of brain tissue, and the changes in lactate levels are crucial in the occurrence and progression of stroke. Lactylation represent a newly discovered process of post-translational modification of proteins, which exerts key physiological and pathological roles in stroke by influencing the lactylation of both histones and non-histones. Here, we review the current research progress on lactate and lactylation in ischemic stroke (IS), discussing the bidirectional regulatory effects of energy metabolism and lactate on inflammatory responses, oxidative stress, neurotoxicity, and neuroplasticity, as well as the cerebrovascular system, along with the effects of lactylation modifications on glycolytic reprogramming and immune function. This new evidence provides broader insights into the epigenetic mechanisms in IS and aids in assessing the feasibility of targeting lactate /lactylation for the treatment of IS.