文献类型：期刊文献

中文题名：固本增骨方联合钙剂辅助治疗脾肾亏虚型骨质疏松症椎体压缩性骨折46例临床观察

英文题名：Clinical observation on Guben Zenggu Fang(固本增骨方)combined with calcium in adjuvant treatment of 46 cases of osteoporotic vertebral compression fractures with consumption of spleen and kidney type

作者：魏敏[1];宋敏[2];董万涛[3];冯宜蒀[3]

第一作者：魏敏

机构：[1]甘肃中医药大学附属医院麻醉手术科,甘肃兰州730020;[2]甘肃中医药大学中医临床学院,甘肃兰州730000;[3]甘肃中医药大学附属医院关节外科,甘肃兰州730020

第一机构：甘肃中医药大学第二附属医院

年份：2019

卷号：36

期号：6

起止页码：57

中文期刊名：甘肃中医药大学学报

外文期刊名：Journal of Gansu University of Chinese Medicine

基金：甘肃省创新基地和人才计划——自然科学基金计划(17JR5RA056)。

语种：中文

中文关键词：骨质疏松症椎体压缩性骨折;脾肾亏虚型;经皮椎体后凸成形术;骨化三醇软胶囊;碳酸钙D3片;固本增骨方;视觉模拟评分法评分;骨密度;临床观察

外文关键词：osteoporotic vertebral compression fractures(OVCFs);consumption of spleen and kidney type;percutaneous kyphoplasty(PKP);calcitriol soft capsules;calcium carbonate and vitamin D3 tablets;Guben Zenggu Fang(固本增骨方);visual analogue scales(VAS);bone mineral density;clinical observation

摘要：目的观察固本增骨方联合钙剂辅助治疗脾肾亏虚型骨质疏松症椎体压缩性骨折的临床疗效。方法将92例脾肾亏虚型骨质疏松症椎体压缩性骨折患者采用随机数字表法分为对照组和治疗组,各46例。2组均给予经皮椎体后凸成形术(PKP)治疗,对照组在PKP治疗的基础上给予骨化三醇软胶囊、碳酸钙D3片口服,治疗组在对照组治疗方法的基础上给予固本增骨方治疗。连续治疗6个月后比较2组的临床疗效、不良反应发生情况,以及治疗前后的视觉模拟评分法(VAS)评分,股骨颈、股骨粗隆骨密度(BMD)。结果对照组总有效率为76.09%,治疗组为91.31%,2组比较差异有统计学意义(P<0.05);治疗后2组VAS评分均明显降低,与同组治疗前比较差异有统计学意义(P<0.05或P<0.01),且治疗组降低更明显,与对照组治疗后比较差异有统计学意义(P<0.05);治疗后2组股骨颈、股骨粗隆BMD均明显升高,与同组治疗前比较差异有统计学意义(P<0.05),且治疗组升高更明显,与对照组治疗后比较差异有统计学意义(P<0.05);对照组不良反应发生率为10.9%,治疗组为8.7%,2组比较差异无统计学意义(P>0.05)。结论固本增骨方联合钙剂辅助治疗脾肾亏虚型骨质疏松症椎体压缩性骨折临床疗效显著,可明显减轻患者疼痛、增加BMD、改善骨质量,且不良反应可控,值得临床推广应用。
Objective To observe the clinical efficacy of Guben Zenggu Fang(固本增骨方)combined with calcium in adjuvant treatment of osteoporotic vertebral compression fractures(OVCFs)with consumption of spleen and kidney type.Methods Ninety-two cases of OVCFs with consumption of spleen and kidney type were divided into control group and treatment group according to random number table method,with 46 cases in each.The 2 groups were both given percutaneous kyphoplasty(PKP),on this basis,the control group was given calcitriol soft capsules and calcium carbonate and vitamin D3 tablets orally,while the treatment group was given Guben Zenggu Fang based on the therapeutic method of the control group.After consecutive treatment for 6 months,the clinical efficacy,the incidence of adverse reactions,visual analogue scales(VAS)score,bone mineral density(BMD)of femoral neck and femoral trochanter before and after treatment of the 2 groups were compared.Results The total effective rate of the control group was 76.09%,that of the treatment group was 91.31%,and the difference was statistically significant between the 2 groups(P<0.05).After treatment,the VAS scores of the 2 groups both significantly decreased,and the difference was statistically significant compared with the same group before treatment(P<0.05 or P<0.01),moreover,the treatment group decreased more significantly,and the difference was statistically significant compared with the control group after treatment(P<0.05).After treatment,the BMD of femoral neck and femoral trochanter in the 2 groups both significantly increased,and the difference was statistically significant compared with the same group before treatment(P<0.05),moreover,the treatment group increased more significantly,and the difference was statistically significant compared with the control group after treatment(P<0.05).The incidence of adverse reactions of the control group was 10.9%,that of the treatment group was 8.7%,and the difference was not statistically significant between the 2 groups(P>0.05).Conclusion It has marked clinical efficacy to use Guben Zenggu Fang combined with calcium in adjuvant treatment of OVCFs with consumption of spleen and kidney type,which can markedly alleviate the pain,increase BMD and improve the bone quality of the patients with controllable adverse reactions.It deserves clinical promotion and application.