文献类型：期刊文献

英文题名：Protective effect of Potentilla anserina polysaccharide on cadmium-induced nephrotoxicity in vitro and in vivo

作者：Shen, Rong[1]; Liu, Disheng[2]; Hou, Chenchen[1]; Leu, Di[1]; Zhao, Lixia[1,4]; Cheng, Ju[1]; Wang, Degui[3]; Bai, Decheng[1]

第一作者：Shen, Rong

通信作者：Wang, Degui

机构：[1] Institute of Integrated Traditional Chinese and Western Medicine, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China; [2] Department of Urologic Surgery, First Hospital, Lanzhou University, Lanzhou, 730000, China; [3] Department of Anatomy and Histology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China; [4] School of Nursing, Gansu University of Chinese Medicine, Lanzhou, 730000, China

第一机构：Institute of Integrated Traditional Chinese and Western Medicine, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China

年份：2017

卷号：8

期号：10

起止页码：3636

外文期刊名：Food and Function

收录：EI(收录号：20174304296342);Scopus(收录号：2-s2.0-85031770822)

语种：英文

外文关键词：Cadmium - Ablation - Mitochondria

摘要：The aim of this research was to investigate the antioxidant and anti-apoptotic activities of Potentilla anserina polysaccharide (PAP) on kidney damage induced by cadmium (Cd) in vitro and in vivo. PAP has been suggested to have anti-oxidation, anti-apoptosis, immunoregulation, antimicrobial, antitussive, and expectorant abilities. In this study, PAP was extracted and the major components of PAP were analyzed. It was shown that PAP pretreatment remarkably improved redox homeostasis, both in human embryonic kidney 293 (HEK293) cells and in BALB/c mice. Administration of PAP attenuated the mitochondrial dysfunction, degeneration, and fibrosis of kidney induced by Cd. Furthermore, PAP exhibited anti-apoptotic activity, which involved regulating both the mitochondria-mediated intrinsic apoptotic pathway and the death receptor-initiated extrinsic pathway. These results suggest that PAP is a potential therapeutic agent for Cd-induced nephrotoxicity. ? 2017 The Royal Society of Chemistry.