文献类型：期刊文献

英文题名：Proton pump inhibitors for the treatment of laryngopharyngeal reflux disease A protocol for systematic review and meta-analysis

作者：Liu, Xiangyi[1,2];Jiang, Ying[2];Luo, Haiyan[2];Liu, Haolin[3]

第一作者：刘翔毅;刘熙钰

通信作者：Liu, XY[1]

机构：[1]Gansu Univ Chinese Med, 35 East Dingxi Rd, Lanzhou 730030, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Gansu, Peoples R China;[3]Tianjin Univ Tradit Chinese Med, Tianjin, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, 35 East Dingxi Rd, Lanzhou 730030, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2020

卷号：99

期号：49

起止页码：E23297

外文期刊名：MEDICINE

收录：;Scopus(收录号：2-s2.0-85097482832);WOS:【SCI-EXPANDED(收录号:WOS:000612838500043)】；

基金：This work was supported by the Teaching reform project of Gansu University of traditional Chinese Medicine,(No.2012-FY03).

语种：英文

外文关键词：laryngopharyngeal reflux disease; meta-analysis; protocol; proton pump inhibitors

摘要：Background: Laryngopharyngeal Reflux disease refers to abnormal reflux of gastric contents through the esophagus into the throat, which irritates and damages the pharyngeal mucosa, and causes corresponding symptoms. Proton Pump Inhibitors are an important class of gastric acid secretion inhibitors after H2 receptor blockers, which can be used clinically to treat peptic ulcer, abnormal gastric acid secretion and other related diseases. The common clinical drugs include omeprazole, lansoprazole, rabeprazole and so on. Clinical practice has shown that Proton Pump Inhibitors have a good therapeutic effect on Laryngopharyngeal Reflux disease, but evidence of evidence-based medicine is lacking. The purpose of this protocol is to systematically evaluate the efficacy and safety of Proton Pump Inhibitors in the treatment of Laryngopharyngeal Reflux disease and to improve the evidence-based basis for the clinical application of Proton Pump Inhibitors in the treatment of Laryngopharyngeal Reflux disease. Methods: English computer retrieval database (PubMed, Embase, Web of Science, the Cochrane Library) and Chinese computer retrieval database (Wanfang Database, VIP Information Chinese Journal Service Platform, Chinese Biomedical Database) . In addition, Baidu Scholar and Google Scholar were manually searched for randomized controlled clinical studies on the treatment of laryngeal reflux disease with Proton Pump Inhibitors from the establishment of the database to July 2020. Two researchers independently extracted and evaluated the data of the included studies, and meta-analysis was conducted on the included literatures with RevMan5.3 software without language restrictions. Results: In this study, the efficacy and safety of Proton Pump Inhibitors in the treatment of Laryngopharyngeal Reflux disease are evaluated by the overall response rate, clinical symptom remission rate and other indicators. Conclusions: This study will provide reliable evidence-based evidence for the clinical application of Proton Pump Inhibitors in the treatment of Laryngopharyngeal Reflux disease. OSF Registration number: DOI 10.17605 / OSF.IO / NY6SC