文献类型：期刊文献

英文题名：Research progress of LINE-1 in the diagnosis, prognosis, and treatment of gynecologic tumors

作者：Fu, Jiaojiao[1,2];Qin, Tiansheng[1,2,3,4];Li, Chaoming[5];Zhu, Jiaojiao[1,2];Ding, Yaoyao[1,2];Zhou, Meiying[2];Yang, Qing[1,2];Liu, Xiaofeng[1,2];Zhou, Juanhong[1,2];Chen, Fan[1,2]

第一作者：Fu, Jiaojiao

通信作者：Qin, TS[1];Chen, F[1];Qin, TS[2];Chen, F[2];Qin, TS[3];Qin, TS[4]

机构：[1]Gansu Univ Chinese Med, Gansu Prov Hosp, Clin Med Coll 1, Lanzhou, Peoples R China;[2]Gansu Prov Hosp, Dept Obstet & Gynecol, Lanzhou, Gansu, Peoples R China;[3]Lanzhou Univ, Clin Med Sch 1, Lanzhou, Gansu, Peoples R China;[4]Gansu Prov Hosp, Natl Hlth Commiss NHC, Key Lab Diag & Therapy Gastrointestinal Tumor, Lanzhou, Gansu, Peoples R China;[5]Longnan City Hosp, Peoples Hosp Longnan 1, Longnan, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Gansu Prov Hosp, Clin Med Coll 1, Lanzhou, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Dept Obstet & Gynecol, Lanzhou, Gansu, Peoples R China;[3]corresponding author), Lanzhou Univ, Clin Med Sch 1, Lanzhou, Gansu, Peoples R China;[4]corresponding author), Gansu Prov Hosp, Natl Hlth Commiss NHC, Key Lab Diag & Therapy Gastrointestinal Tumor, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2023

卷号：13

外文期刊名：FRONTIERS IN ONCOLOGY

收录：;Scopus(收录号：2-s2.0-85166970188);WOS:【SCI-EXPANDED(收录号:WOS:001039889200001)】；

语种：英文

外文关键词：gynecologic cancers; retrotransposons; diagnostic; therapy; prognosis

摘要：The retrotransposon known as long interspersed nuclear element-1 (LINE-1), which is currently the sole autonomously mobile transposon in the human genome, can result in insertional mutations, chromosomal rearrangements, and genomic instability. In recent years, numerous studies have shown that LINE-1 is involved in the development of various diseases and also plays an important role in the immune regulation of the organism. The expression of LINE-1 in gynecologic tumors suggests that it is expected to be an independent indicator for early diagnosis and prognosis, and also, as a therapeutic target, LINE-1 is closely associated with gynecologic tumor prognosis. This article discusses the function of LINE-1 in the diagnosis, treatment, and prognosis of ovarian, cervical, and endometrial malignancies, as well as other gynecologic malignancies. It offers fresh perspectives on the early detection of tumors and the creation of novel anti-tumor medications.